Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications

Background and aimsInflammatory bowel disease (IBD), mainly categorized into Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic relapsing gastrointestinal disorder that significantly impairs patients’ quality of life. IBD patients often experience comorbidities such as anxiety and depres...

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Main Authors: Fan Li, Qi Zhao, Tongyu Tang, Yuyuan Liu, Zhaodi Wang, Zhi Wang, Xiaoping Han, Zifeng Xu, Yu Chang, Yuqin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1359540/full
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author Fan Li
Fan Li
Qi Zhao
Qi Zhao
Tongyu Tang
Yuyuan Liu
Yuyuan Liu
Zhaodi Wang
Zhaodi Wang
Zhi Wang
Zhi Wang
Xiaoping Han
Xiaoping Han
Zifeng Xu
Zifeng Xu
Yu Chang
Yu Chang
Yuqin Li
author_facet Fan Li
Fan Li
Qi Zhao
Qi Zhao
Tongyu Tang
Yuyuan Liu
Yuyuan Liu
Zhaodi Wang
Zhaodi Wang
Zhi Wang
Zhi Wang
Xiaoping Han
Xiaoping Han
Zifeng Xu
Zifeng Xu
Yu Chang
Yu Chang
Yuqin Li
author_sort Fan Li
collection DOAJ
description Background and aimsInflammatory bowel disease (IBD), mainly categorized into Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic relapsing gastrointestinal disorder that significantly impairs patients’ quality of life. IBD patients often experience comorbidities such as anxiety and depression, and the underlying mechanisms and treatment strategies remain areas of investigation.MethodsWe conducted a Mendelian randomization(MR) analysis utilizing brain image derived phenotypes (IDP) from the UK Biobank database to investigate the causal relationships between IBD and alterations in brain structural morphology and connectivity of neural tracts. This study aimed to identify biological evidence linking IBD to psychiatric disorders such as anxiety and depression.ResultsSpecifically, the volume of grey matter in the Left Frontal Orbital Cortex exhibited a negative association with the onset of Crohn’s disease (odds ratio (OR) [95% confidence interval (CI)]: 0.315[0.180~0.551], adjusted P=0.001), while the volume of the superior frontal cortex in the right hemisphere showed a positive correlation with the development of Ulcerative colitis (OR [95% CI]: 2.285[1.793~2.911], adjusted P<0.001), and the volume of lateral occipital cortex in the left hemisphere demonstrated a positive relationship with Crohn’s disease onset (OR [95% CI]: 1.709[1.671~1.747], adjusted P<0.001). In the context of reverse causality, the onset of UC or CD has led to alterations in imaging derived phenotypes associated with five disorders (anxiety, depression, schizophrenia, bipolar disorder, pain) and three functions (memory, emotion, language).ConclusionOur study has demonstrated a causal relationship between IBD and IDPs. IDPs may serve as potential biomarkers for the progression of IBD and as predictive intermediaries for the development of neurological diseases in IBD patients.
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spelling doaj.art-b5cb28170b064f11b4259520349f6f092024-02-26T04:43:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13595401359540Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complicationsFan Li0Fan Li1Qi Zhao2Qi Zhao3Tongyu Tang4Yuyuan Liu5Yuyuan Liu6Zhaodi Wang7Zhaodi Wang8Zhi Wang9Zhi Wang10Xiaoping Han11Xiaoping Han12Zifeng Xu13Zifeng Xu14Yu Chang15Yu Chang16Yuqin Li17Department of Gastroenterology, The First Hospital of Jilin University, Changchun, ChinaNorman Bethune Health Science Center, Jilin University, Changchun, ChinaDepartment of Gastroenterology, The First Hospital of Jilin University, Changchun, ChinaNorman Bethune Health Science Center, Jilin University, Changchun, ChinaDepartment of Gastroenterology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Gastroenterology, The First Hospital of Jilin University, Changchun, ChinaNorman Bethune Health Science Center, Jilin University, Changchun, ChinaDepartment of Gastroenterology, The First Hospital of Jilin University, Changchun, ChinaNorman Bethune Health Science Center, Jilin University, Changchun, ChinaDepartment of Gastroenterology, The First Hospital of Jilin University, Changchun, ChinaNorman Bethune Health Science Center, Jilin University, Changchun, ChinaDepartment of Gastroenterology, The First Hospital of Jilin University, Changchun, ChinaNorman Bethune Health Science Center, Jilin University, Changchun, ChinaDepartment of Gastroenterology, The First Hospital of Jilin University, Changchun, ChinaNorman Bethune Health Science Center, Jilin University, Changchun, ChinaDepartment of Gastroenterology, The First Hospital of Jilin University, Changchun, ChinaNorman Bethune Health Science Center, Jilin University, Changchun, ChinaDepartment of Gastroenterology, The First Hospital of Jilin University, Changchun, ChinaBackground and aimsInflammatory bowel disease (IBD), mainly categorized into Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic relapsing gastrointestinal disorder that significantly impairs patients’ quality of life. IBD patients often experience comorbidities such as anxiety and depression, and the underlying mechanisms and treatment strategies remain areas of investigation.MethodsWe conducted a Mendelian randomization(MR) analysis utilizing brain image derived phenotypes (IDP) from the UK Biobank database to investigate the causal relationships between IBD and alterations in brain structural morphology and connectivity of neural tracts. This study aimed to identify biological evidence linking IBD to psychiatric disorders such as anxiety and depression.ResultsSpecifically, the volume of grey matter in the Left Frontal Orbital Cortex exhibited a negative association with the onset of Crohn’s disease (odds ratio (OR) [95% confidence interval (CI)]: 0.315[0.180~0.551], adjusted P=0.001), while the volume of the superior frontal cortex in the right hemisphere showed a positive correlation with the development of Ulcerative colitis (OR [95% CI]: 2.285[1.793~2.911], adjusted P<0.001), and the volume of lateral occipital cortex in the left hemisphere demonstrated a positive relationship with Crohn’s disease onset (OR [95% CI]: 1.709[1.671~1.747], adjusted P<0.001). In the context of reverse causality, the onset of UC or CD has led to alterations in imaging derived phenotypes associated with five disorders (anxiety, depression, schizophrenia, bipolar disorder, pain) and three functions (memory, emotion, language).ConclusionOur study has demonstrated a causal relationship between IBD and IDPs. IDPs may serve as potential biomarkers for the progression of IBD and as predictive intermediaries for the development of neurological diseases in IBD patients.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1359540/fullMendelian randomizationimaging derived phenotypesulcerative colitisCrohn’s diseaseinflammatory bowel disease
spellingShingle Fan Li
Fan Li
Qi Zhao
Qi Zhao
Tongyu Tang
Yuyuan Liu
Yuyuan Liu
Zhaodi Wang
Zhaodi Wang
Zhi Wang
Zhi Wang
Xiaoping Han
Xiaoping Han
Zifeng Xu
Zifeng Xu
Yu Chang
Yu Chang
Yuqin Li
Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications
Frontiers in Immunology
Mendelian randomization
imaging derived phenotypes
ulcerative colitis
Crohn’s disease
inflammatory bowel disease
title Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications
title_full Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications
title_fullStr Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications
title_full_unstemmed Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications
title_short Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications
title_sort brain imaging derived phenotypes a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications
topic Mendelian randomization
imaging derived phenotypes
ulcerative colitis
Crohn’s disease
inflammatory bowel disease
url https://www.frontiersin.org/articles/10.3389/fimmu.2024.1359540/full
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