Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1

A defining feature of mitochondria is their maternal mode of inheritance. However, little is understood about the cellular mechanism through which paternal mitochondria, delivered from sperm, are eliminated from early mammalian embryos. Autophagy has been implicated in nematodes, but whether this me...

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Bibliografski detalji
Glavni autori: Rebecca Rojansky, Moon-Yong Cha, David C Chan
Format: Članak
Jezik:English
Izdano: eLife Sciences Publications Ltd 2016-11-01
Serija:eLife
Teme:
Online pristup:https://elifesciences.org/articles/17896