Recognition of tumor-targeting peptide P7 related to the expression level of Hsp90
Objective To analyze the correlation between the expression of heat shock protein 90 (Hsp90) and the recognition of LPLTPLP (P7) on different tumor tissues and para-carcinoma tissues. Methods The expression of HSP90 and recognition effects of FITC-P7 in 48 cases of patients with 16 types of orga...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2021-07-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a210391.pdf |
| _version_ | 1797365808296361984 |
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| author | KONG De-xin, HUANG Wei, YANG Nan, LIU Yan-yong |
| author_facet | KONG De-xin, HUANG Wei, YANG Nan, LIU Yan-yong |
| author_sort | KONG De-xin, HUANG Wei, YANG Nan, LIU Yan-yong |
| collection | DOAJ |
| description | Objective To analyze the correlation between the expression of heat shock protein 90 (Hsp90) and the recognition of LPLTPLP (P7) on different tumor tissues and para-carcinoma tissues. Methods The expression of HSP90 and recognition effects of FITC-P7 in 48 cases of patients with 16 types of organ tumors and matched or mismatched marginal or adjacent tissues were analyzed by immunohistochemistry and immunofluorescence, respectively. Results Hsp90 was highly expressed in tumor tissues than para-carcinoma tissues. FITC-P7 showed a preferred recognition effect on tumor tissues in proportion to Hsp90 expression levels as determined by immunohistochemistry. There was moderate correlation in the two groups of data (r=0.5147,P＜0.01). Conclusions The recognition of tumor tissues by P7 is positively related to the expression level of Hsp90, suggesting the targeting of P7 at Hsp90. |
| first_indexed | 2024-03-08T16:54:11Z |
| format | Article |
| id | doaj.art-b5cdccd001af4bae8e409bdcc1f5b8a6 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:54:11Z |
| publishDate | 2021-07-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-b5cdccd001af4bae8e409bdcc1f5b8a62024-01-05T03:05:36ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252021-07-01417982987Recognition of tumor-targeting peptide P7 related to the expression level of Hsp90KONG De-xin, HUANG Wei, YANG Nan, LIU Yan-yong0Department of Pharmacology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005, ChinaObjective To analyze the correlation between the expression of heat shock protein 90 (Hsp90) and the recognition of LPLTPLP (P7) on different tumor tissues and para-carcinoma tissues. Methods The expression of HSP90 and recognition effects of FITC-P7 in 48 cases of patients with 16 types of organ tumors and matched or mismatched marginal or adjacent tissues were analyzed by immunohistochemistry and immunofluorescence, respectively. Results Hsp90 was highly expressed in tumor tissues than para-carcinoma tissues. FITC-P7 showed a preferred recognition effect on tumor tissues in proportion to Hsp90 expression levels as determined by immunohistochemistry. There was moderate correlation in the two groups of data (r=0.5147,P＜0.01). Conclusions The recognition of tumor tissues by P7 is positively related to the expression level of Hsp90, suggesting the targeting of P7 at Hsp90.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a210391.pdfheat shock protein 90(hsp90)|polypeptide|correlation analysis |
| spellingShingle | KONG De-xin, HUANG Wei, YANG Nan, LIU Yan-yong Recognition of tumor-targeting peptide P7 related to the expression level of Hsp90 Jichu yixue yu linchuang heat shock protein 90(hsp90)|polypeptide|correlation analysis |
| title | Recognition of tumor-targeting peptide P7 related to the expression level of Hsp90 |
| title_full | Recognition of tumor-targeting peptide P7 related to the expression level of Hsp90 |
| title_fullStr | Recognition of tumor-targeting peptide P7 related to the expression level of Hsp90 |
| title_full_unstemmed | Recognition of tumor-targeting peptide P7 related to the expression level of Hsp90 |
| title_short | Recognition of tumor-targeting peptide P7 related to the expression level of Hsp90 |
| title_sort | recognition of tumor targeting peptide p7 related to the expression level of hsp90 |
| topic | heat shock protein 90(hsp90)|polypeptide|correlation analysis |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a210391.pdf |
| work_keys_str_mv | AT kongdexinhuangweiyangnanliuyanyong recognitionoftumortargetingpeptidep7relatedtotheexpressionlevelofhsp90 |