Prognostic Value of Postoperative Neutrophil and Albumin: Reassessment One Month After Gastric Cancer Surgery
ObjectiveThe prognostic value of postoperative parameters reflecting the inflammatory and nutritional status of patients undergoing cancer surgery has been rarely studied. This study investigated the prognostic value of inflammatory and nutritional parameters measured preoperatively and 1 month afte...
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| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.633924/full |
| _version_ | 1818440846311161856 |
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| author | Ali Guner Ali Guner Minah Cho Minah Cho Minah Cho Yoo-Min Kim Yoo-Min Kim Yoo-Min Kim Jae-Ho Cheong Jae-Ho Cheong Jae-Ho Cheong Woo Jin Hyung Woo Jin Hyung Woo Jin Hyung Hyoung-Il Kim Hyoung-Il Kim Hyoung-Il Kim |
| author_facet | Ali Guner Ali Guner Minah Cho Minah Cho Minah Cho Yoo-Min Kim Yoo-Min Kim Yoo-Min Kim Jae-Ho Cheong Jae-Ho Cheong Jae-Ho Cheong Woo Jin Hyung Woo Jin Hyung Woo Jin Hyung Hyoung-Il Kim Hyoung-Il Kim Hyoung-Il Kim |
| author_sort | Ali Guner |
| collection | DOAJ |
| description | ObjectiveThe prognostic value of postoperative parameters reflecting the inflammatory and nutritional status of patients undergoing cancer surgery has been rarely studied. This study investigated the prognostic value of inflammatory and nutritional parameters measured preoperatively and 1 month after curative gastrectomy for gastric cancer.MethodsData from a prospectively maintained database of 1,194 patients with gastric cancer who underwent curative surgery in 2009–2018 were retrospectively reviewed. Demographics, clinicopathologic characteristics, operative data, survival data, and laboratory parameters were extracted. Neutrophil counts, lymphocyte counts, and albumin levels before surgery and 1 month postoperatively were analyzed.ResultsIn multivariable analysis adjusted for age, sex, and pathologic stage, high neutrophil count (hazard ratio [HR] 1.09, 95% confidence interval [CI] 1.01–1.17, p = 0.022) and low albumin (HR 0.45, 95% CI 0.27–0.74, p = 0.002) 1 month postoperatively were independent prognostic factors for overall survival. High neutrophil count (HR 1.09, 95% CI 1.02–1.16, p = 0.015) 1 month postoperatively was also an independent prognostic factor for recurrence-free survival after adjusting for age, sex, body mass index, extent of gastrectomy, and pathologic stage. Patients were classified into risk groups based on thresholds of 4.2 × 103 cells/mm3 and 4.1 g/dl for 1-month neutrophil count and albumin. High-risk groups had a significantly worse prognosis than low-risk groups for overall survival (HR 5.87, 95% CI 3.28–10.51, p <0.001) and recurrence-free survival (HR 1.52, 95% CI 1.07–2.16, p = 0.021).ConclusionsNeutrophil count and albumin level 1 month after curative surgery reflect long-term prognosis better than preoperative values. These parameters can be used to stratify patients with the same stage into different prognostic groups. |
| first_indexed | 2024-12-14T18:18:51Z |
| format | Article |
| id | doaj.art-b5cfb3e8a98442189e0391eb5a72e749 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T18:18:51Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b5cfb3e8a98442189e0391eb5a72e7492022-12-21T22:52:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.633924633924Prognostic Value of Postoperative Neutrophil and Albumin: Reassessment One Month After Gastric Cancer SurgeryAli Guner0Ali Guner1Minah Cho2Minah Cho3Minah Cho4Yoo-Min Kim5Yoo-Min Kim6Yoo-Min Kim7Jae-Ho Cheong8Jae-Ho Cheong9Jae-Ho Cheong10Woo Jin Hyung11Woo Jin Hyung12Woo Jin Hyung13Hyoung-Il Kim14Hyoung-Il Kim15Hyoung-Il Kim16Department of Surgery, Yonsei University College of Medicine, Seoul, South KoreaFaculty of Medicine, Department of General Surgery, Karadeniz Technical University, Trabzon, TurkeyDepartment of Surgery, Yonsei University College of Medicine, Seoul, South KoreaGastric Cancer Center, Yonsei Cancer Center, Seoul, South KoreaOpen NBI Convergence Technology Research Laboratory, Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Surgery, Yonsei University College of Medicine, Seoul, South KoreaGastric Cancer Center, Yonsei Cancer Center, Seoul, South KoreaOpen NBI Convergence Technology Research Laboratory, Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Surgery, Yonsei University College of Medicine, Seoul, South KoreaGastric Cancer Center, Yonsei Cancer Center, Seoul, South KoreaOpen NBI Convergence Technology Research Laboratory, Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Surgery, Yonsei University College of Medicine, Seoul, South KoreaGastric Cancer Center, Yonsei Cancer Center, Seoul, South KoreaOpen NBI Convergence Technology Research Laboratory, Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Surgery, Yonsei University College of Medicine, Seoul, South KoreaGastric Cancer Center, Yonsei Cancer Center, Seoul, South KoreaOpen NBI Convergence Technology Research Laboratory, Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South KoreaObjectiveThe prognostic value of postoperative parameters reflecting the inflammatory and nutritional status of patients undergoing cancer surgery has been rarely studied. This study investigated the prognostic value of inflammatory and nutritional parameters measured preoperatively and 1 month after curative gastrectomy for gastric cancer.MethodsData from a prospectively maintained database of 1,194 patients with gastric cancer who underwent curative surgery in 2009–2018 were retrospectively reviewed. Demographics, clinicopathologic characteristics, operative data, survival data, and laboratory parameters were extracted. Neutrophil counts, lymphocyte counts, and albumin levels before surgery and 1 month postoperatively were analyzed.ResultsIn multivariable analysis adjusted for age, sex, and pathologic stage, high neutrophil count (hazard ratio [HR] 1.09, 95% confidence interval [CI] 1.01–1.17, p = 0.022) and low albumin (HR 0.45, 95% CI 0.27–0.74, p = 0.002) 1 month postoperatively were independent prognostic factors for overall survival. High neutrophil count (HR 1.09, 95% CI 1.02–1.16, p = 0.015) 1 month postoperatively was also an independent prognostic factor for recurrence-free survival after adjusting for age, sex, body mass index, extent of gastrectomy, and pathologic stage. Patients were classified into risk groups based on thresholds of 4.2 × 103 cells/mm3 and 4.1 g/dl for 1-month neutrophil count and albumin. High-risk groups had a significantly worse prognosis than low-risk groups for overall survival (HR 5.87, 95% CI 3.28–10.51, p <0.001) and recurrence-free survival (HR 1.52, 95% CI 1.07–2.16, p = 0.021).ConclusionsNeutrophil count and albumin level 1 month after curative surgery reflect long-term prognosis better than preoperative values. These parameters can be used to stratify patients with the same stage into different prognostic groups.https://www.frontiersin.org/articles/10.3389/fonc.2021.633924/fullstomach neoplasmsinflammationneutrophilsalbuminprognosissurvival |
| spellingShingle | Ali Guner Ali Guner Minah Cho Minah Cho Minah Cho Yoo-Min Kim Yoo-Min Kim Yoo-Min Kim Jae-Ho Cheong Jae-Ho Cheong Jae-Ho Cheong Woo Jin Hyung Woo Jin Hyung Woo Jin Hyung Hyoung-Il Kim Hyoung-Il Kim Hyoung-Il Kim Prognostic Value of Postoperative Neutrophil and Albumin: Reassessment One Month After Gastric Cancer Surgery Frontiers in Oncology stomach neoplasms inflammation neutrophils albumin prognosis survival |
| title | Prognostic Value of Postoperative Neutrophil and Albumin: Reassessment One Month After Gastric Cancer Surgery |
| title_full | Prognostic Value of Postoperative Neutrophil and Albumin: Reassessment One Month After Gastric Cancer Surgery |
| title_fullStr | Prognostic Value of Postoperative Neutrophil and Albumin: Reassessment One Month After Gastric Cancer Surgery |
| title_full_unstemmed | Prognostic Value of Postoperative Neutrophil and Albumin: Reassessment One Month After Gastric Cancer Surgery |
| title_short | Prognostic Value of Postoperative Neutrophil and Albumin: Reassessment One Month After Gastric Cancer Surgery |
| title_sort | prognostic value of postoperative neutrophil and albumin reassessment one month after gastric cancer surgery |
| topic | stomach neoplasms inflammation neutrophils albumin prognosis survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.633924/full |
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