Endothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice

Endothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice

Abstract Purpose Heparan sulfate (HS) is one of the factors that has been suggested to be associated with angiogenesis and invasion of glioblastoma (GBM), an aggressive and fast-growing brain tumor. However, it remains unclear how HS of endothelial cells is involved in angiogenesis in glioblastoma a...

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Main Authors: Takamasa Kinoshita, Hiroyuki Tomita, Hideshi Okada, Ayumi Niwa, Fuminori Hyodo, Tomohiro Kanayama, Mikiko Matsuo, Yuko Imaizumi, Takahiro Kuroda, Yuichiro Hatano, Masafumi Miyai, Yusuke Egashira, Yukiko Enomoto, Noriyuki Nakayama, Shigeyuki Sugie, Kazu Matsumoto, Yu Yamaguchi, Masayuki Matsuo, Hideaki Hara, Toru Iwama, Akira Hara
Format: Article
Language:English
Published: Springer 2021-11-01
Series:Discover Oncology
Subjects:
Glioblastoma
Angiogenesis
Heparan sulfate
Fibroblast growth factor 2
Online Access:https://doi.org/10.1007/s12672-021-00444-3

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