Coronary Artery Formation Is Driven by Localized Expression of R-spondin3
Coronary arteries are essential to support the heart with oxygen, and coronary heart disease is one of the leading causes of death worldwide. The coronary arteries form at highly stereotyped locations and are derived from the primitive vascular plexus of the heart. How coronary arteries are remodele...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-08-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717310744 |
| _version_ | 1819081194178871296 |
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| author | Fabio Da Silva Ana Sofia Rocha Fariba Jian Motamedi Filippo Massa Cem Basboga Harris Morrison Kay Dietrich Wagner Andreas Schedl |
| author_facet | Fabio Da Silva Ana Sofia Rocha Fariba Jian Motamedi Filippo Massa Cem Basboga Harris Morrison Kay Dietrich Wagner Andreas Schedl |
| author_sort | Fabio Da Silva |
| collection | DOAJ |
| description | Coronary arteries are essential to support the heart with oxygen, and coronary heart disease is one of the leading causes of death worldwide. The coronary arteries form at highly stereotyped locations and are derived from the primitive vascular plexus of the heart. How coronary arteries are remodeled and the signaling molecules that govern this process are poorly understood. Here, we have identified the Wnt-signaling modulator Rspo3 as a crucial regulator of coronary artery formation in the developing heart. Rspo3 is specifically expressed around the coronary stems at critical time points in their development. Temporal ablation of Rspo3 at E11.5 leads to decreased β-catenin signaling and a reduction in arterial-specific proliferation. As a result, the coronary stems are defective and the arterial tree does not form properly. These results identify a mechanism through which localized expression of RSPO3 induces proliferation of the coronary arteries at their stems and permits their formation. |
| first_indexed | 2024-12-21T19:56:54Z |
| format | Article |
| id | doaj.art-b5d3959c5e6d460b9214ee8e84f439d9 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-21T19:56:54Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-b5d3959c5e6d460b9214ee8e84f439d92022-12-21T18:52:04ZengElsevierCell Reports2211-12472017-08-012081745175410.1016/j.celrep.2017.08.004Coronary Artery Formation Is Driven by Localized Expression of R-spondin3Fabio Da Silva0Ana Sofia Rocha1Fariba Jian Motamedi2Filippo Massa3Cem Basboga4Harris Morrison5Kay Dietrich Wagner6Andreas Schedl7Université Côte d’Azur, Inserm, CNRS, iBV, Nice, 06108, FranceUniversité Côte d’Azur, Inserm, CNRS, iBV, Nice, 06108, FranceUniversité Côte d’Azur, Inserm, CNRS, iBV, Nice, 06108, FranceUniversité Côte d’Azur, Inserm, CNRS, iBV, Nice, 06108, FranceUniversité Côte d’Azur, Inserm, CNRS, iBV, Nice, 06108, FranceMRC Human Genetics Unit, Western General Hospital, Edinburgh EH42XU, UKUniversité Côte d’Azur, Inserm, CNRS, iBV, Nice, 06108, FranceUniversité Côte d’Azur, Inserm, CNRS, iBV, Nice, 06108, FranceCoronary arteries are essential to support the heart with oxygen, and coronary heart disease is one of the leading causes of death worldwide. The coronary arteries form at highly stereotyped locations and are derived from the primitive vascular plexus of the heart. How coronary arteries are remodeled and the signaling molecules that govern this process are poorly understood. Here, we have identified the Wnt-signaling modulator Rspo3 as a crucial regulator of coronary artery formation in the developing heart. Rspo3 is specifically expressed around the coronary stems at critical time points in their development. Temporal ablation of Rspo3 at E11.5 leads to decreased β-catenin signaling and a reduction in arterial-specific proliferation. As a result, the coronary stems are defective and the arterial tree does not form properly. These results identify a mechanism through which localized expression of RSPO3 induces proliferation of the coronary arteries at their stems and permits their formation.http://www.sciencedirect.com/science/article/pii/S2211124717310744coronary arterycoronary formationendothelial proliferationR-spondin3β-cateninWnt signaling |
| spellingShingle | Fabio Da Silva Ana Sofia Rocha Fariba Jian Motamedi Filippo Massa Cem Basboga Harris Morrison Kay Dietrich Wagner Andreas Schedl Coronary Artery Formation Is Driven by Localized Expression of R-spondin3 Cell Reports coronary artery coronary formation endothelial proliferation R-spondin3 β-catenin Wnt signaling |
| title | Coronary Artery Formation Is Driven by Localized Expression of R-spondin3 |
| title_full | Coronary Artery Formation Is Driven by Localized Expression of R-spondin3 |
| title_fullStr | Coronary Artery Formation Is Driven by Localized Expression of R-spondin3 |
| title_full_unstemmed | Coronary Artery Formation Is Driven by Localized Expression of R-spondin3 |
| title_short | Coronary Artery Formation Is Driven by Localized Expression of R-spondin3 |
| title_sort | coronary artery formation is driven by localized expression of r spondin3 |
| topic | coronary artery coronary formation endothelial proliferation R-spondin3 β-catenin Wnt signaling |
| url | http://www.sciencedirect.com/science/article/pii/S2211124717310744 |
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