Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial
Background Meta‐analyses have shown that isometric handgrip training (IHT) can reduce brachial systolic and diastolic blood pressure (BP) by >6/4 mm Hg, respectively. However, whether IHT promotes these effects among patients with peripheral artery disease, who exhibit severe impairment in cardio...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-02-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.013596 |
| _version_ | 1797884431854206976 |
|---|---|
| author | Marilia A. Correia Paulo L. Oliveira Breno Q. Farah Lauro C. Vianna Nelson Wolosker Pedro Puech‐Leao Daniel J. Green Gabriel G. Cucato Raphael M. Ritti‐Dias |
| author_facet | Marilia A. Correia Paulo L. Oliveira Breno Q. Farah Lauro C. Vianna Nelson Wolosker Pedro Puech‐Leao Daniel J. Green Gabriel G. Cucato Raphael M. Ritti‐Dias |
| author_sort | Marilia A. Correia |
| collection | DOAJ |
| description | Background Meta‐analyses have shown that isometric handgrip training (IHT) can reduce brachial systolic and diastolic blood pressure (BP) by >6/4 mm Hg, respectively. However, whether IHT promotes these effects among patients with peripheral artery disease, who exhibit severe impairment in cardiovascular function, is currently unknown. This study aimed to evaluate the effects of IHT on the cardiovascular function of patients with peripheral artery disease. Methods and Results A randomized controlled trial with peripheral artery disease patients assigned to either the IHT or control group was conducted. The IHT group performed 3 sessions per week, for 8 weeks, of unilateral handgrip exercises, consisting of 4 sets of isometric contractions for 2 minutes at 30% of maximum voluntary contraction and a 4‐minute interval between sets. The control group received a compression ball in order to minimize the placebo effects, representing sham training. The primary outcome was brachial BP. The secondary outcomes were central BP, arterial stiffness parameters, cardiac autonomic modulation, and vascular function. The IHT program reduced diastolic BP (75 [10] mm Hg preintervention versus 72 [11] mm Hg postintervention), with no change in the control group (74 [11] mm Hg preintervention versus 74 [11] mm Hg postintervention), with this between‐group difference being significant (P=0.04). Flow‐mediated dilation improved in the IHT group (6.0% [5.7] preintervention versus 9.7% [5.5] postintervention), with no change in the control group (7.6% [5.5] preintervention versus 7.4% [5.1] postintervention), with this between‐group difference being significant (P=0.04). There was no change in other measured variables over the intervention period. Conclusions IHT reduced brachial diastolic BP and improved local vascular function in patients with peripheral artery disease. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT02742220. |
| first_indexed | 2024-04-10T04:06:10Z |
| format | Article |
| id | doaj.art-b5d65c9bc3fa4913aeb5cf51952745ec |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-10T04:06:10Z |
| publishDate | 2020-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-b5d65c9bc3fa4913aeb5cf51952745ec2023-03-13T05:25:33ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-02-019410.1161/JAHA.119.013596Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled TrialMarilia A. Correia0Paulo L. Oliveira1Breno Q. Farah2Lauro C. Vianna3Nelson Wolosker4Pedro Puech‐Leao5Daniel J. Green6Gabriel G. Cucato7Raphael M. Ritti‐Dias8Associated Graduated Program in Physical Education Universidade de Pernambuco e Universidade da Paraíba Recife BrazilGraduated Program in Rehabilitation Sciences Universidade Nove de Julho São Paulo BrazilFederal Rural University of Pernambuco Recife BrazilFaculty of Physical Education Universidade de Brasília Brasília BrazilHospital Israelita Albert Einstein São Paulo BrazilFaculty of Medicine University of São Paulo BrazilThe University of Western Australia Perth AustraliaHospital Israelita Albert Einstein São Paulo BrazilGraduated Program in Rehabilitation Sciences Universidade Nove de Julho São Paulo BrazilBackground Meta‐analyses have shown that isometric handgrip training (IHT) can reduce brachial systolic and diastolic blood pressure (BP) by >6/4 mm Hg, respectively. However, whether IHT promotes these effects among patients with peripheral artery disease, who exhibit severe impairment in cardiovascular function, is currently unknown. This study aimed to evaluate the effects of IHT on the cardiovascular function of patients with peripheral artery disease. Methods and Results A randomized controlled trial with peripheral artery disease patients assigned to either the IHT or control group was conducted. The IHT group performed 3 sessions per week, for 8 weeks, of unilateral handgrip exercises, consisting of 4 sets of isometric contractions for 2 minutes at 30% of maximum voluntary contraction and a 4‐minute interval between sets. The control group received a compression ball in order to minimize the placebo effects, representing sham training. The primary outcome was brachial BP. The secondary outcomes were central BP, arterial stiffness parameters, cardiac autonomic modulation, and vascular function. The IHT program reduced diastolic BP (75 [10] mm Hg preintervention versus 72 [11] mm Hg postintervention), with no change in the control group (74 [11] mm Hg preintervention versus 74 [11] mm Hg postintervention), with this between‐group difference being significant (P=0.04). Flow‐mediated dilation improved in the IHT group (6.0% [5.7] preintervention versus 9.7% [5.5] postintervention), with no change in the control group (7.6% [5.5] preintervention versus 7.4% [5.1] postintervention), with this between‐group difference being significant (P=0.04). There was no change in other measured variables over the intervention period. Conclusions IHT reduced brachial diastolic BP and improved local vascular function in patients with peripheral artery disease. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT02742220.https://www.ahajournals.org/doi/10.1161/JAHA.119.013596blood pressurecardiovascular systemintermittent claudicationperipheral vascular disease |
| spellingShingle | Marilia A. Correia Paulo L. Oliveira Breno Q. Farah Lauro C. Vianna Nelson Wolosker Pedro Puech‐Leao Daniel J. Green Gabriel G. Cucato Raphael M. Ritti‐Dias Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease blood pressure cardiovascular system intermittent claudication peripheral vascular disease |
| title | Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial |
| title_full | Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial |
| title_fullStr | Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial |
| title_full_unstemmed | Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial |
| title_short | Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial |
| title_sort | effects of isometric handgrip training in patients with peripheral artery disease a randomized controlled trial |
| topic | blood pressure cardiovascular system intermittent claudication peripheral vascular disease |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.013596 |
| work_keys_str_mv | AT mariliaacorreia effectsofisometrichandgriptraininginpatientswithperipheralarterydiseasearandomizedcontrolledtrial AT paulololiveira effectsofisometrichandgriptraininginpatientswithperipheralarterydiseasearandomizedcontrolledtrial AT brenoqfarah effectsofisometrichandgriptraininginpatientswithperipheralarterydiseasearandomizedcontrolledtrial AT laurocvianna effectsofisometrichandgriptraininginpatientswithperipheralarterydiseasearandomizedcontrolledtrial AT nelsonwolosker effectsofisometrichandgriptraininginpatientswithperipheralarterydiseasearandomizedcontrolledtrial AT pedropuechleao effectsofisometrichandgriptraininginpatientswithperipheralarterydiseasearandomizedcontrolledtrial AT danieljgreen effectsofisometrichandgriptraininginpatientswithperipheralarterydiseasearandomizedcontrolledtrial AT gabrielgcucato effectsofisometrichandgriptraininginpatientswithperipheralarterydiseasearandomizedcontrolledtrial AT raphaelmrittidias effectsofisometrichandgriptraininginpatientswithperipheralarterydiseasearandomizedcontrolledtrial |