Insights into the Novel Therapeutics and Vaccines against Herpes Simplex Virus
Herpes simplex virus (HSV) is a great concern of the global health community due to its linked infection of inconspicuous nature and resultant serious medical consequences. Seropositive patients may develop ocular disease or genital herpes as characteristic infectious outcomes. Moreover, the infecti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/2/325 |
| _version_ | 1797617941919825920 |
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| author | Shiza Malik Ranjit Sah Omar Ahsan Khalid Muhammad Yasir Waheed |
| author_facet | Shiza Malik Ranjit Sah Omar Ahsan Khalid Muhammad Yasir Waheed |
| author_sort | Shiza Malik |
| collection | DOAJ |
| description | Herpes simplex virus (HSV) is a great concern of the global health community due to its linked infection of inconspicuous nature and resultant serious medical consequences. Seropositive patients may develop ocular disease or genital herpes as characteristic infectious outcomes. Moreover, the infectious nature of HSV is so complex that the available therapeutic options have been modified in certain ways to cure it. However, no permanent and highly effective cure has been discovered. This review generates insights into the available prophylactic and therapeutic interventions against HSV. A methodological research approach is used for study design and data complication. Only the latest data from publications are acquired to shed light on updated therapeutic approaches. These studies indicate that the current antiviral therapeutics can suppress the symptoms and control viral transmission up to a certain level, but cannot eradicate the natural HSV infection and latency outcomes. Most trials that have entered the clinical phase are made part of this review to understand what is new within the field. Some vaccination approaches are also discussed. Moreover, some novel therapeutic options that are currently in research annals are given due consideration for future development. The data can enable the scientific community to direct their efforts to fill the gaps that remain unfilled in terms of therapies for HSV. The need is to integrate scientific efforts to produce a proper cure against HSV to control the virus spread, resistance, and mutation in future disease management. |
| first_indexed | 2024-03-11T08:02:07Z |
| format | Article |
| id | doaj.art-b5d8fd4069c64f40a61a068485760f5d |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T08:02:07Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-b5d8fd4069c64f40a61a068485760f5d2023-11-16T23:42:50ZengMDPI AGVaccines2076-393X2023-01-0111232510.3390/vaccines11020325Insights into the Novel Therapeutics and Vaccines against Herpes Simplex VirusShiza Malik0Ranjit Sah1Omar Ahsan2Khalid Muhammad3Yasir Waheed4Bridging Health Foundation, Rawalpindi 46000, PakistanDepartment of Microbiology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu 44600, NepalDepartment of Medicine, School of Health Sciences, Foundation University Islamabad, DHA Phase I, Islamabad 44000, PakistanDepartment of Biology, College of Science, UAE University, Al Ain 15551, United Arab EmiratesOffice of Research, Innovation, and Commercialization (ORIC), Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad 44000, PakistanHerpes simplex virus (HSV) is a great concern of the global health community due to its linked infection of inconspicuous nature and resultant serious medical consequences. Seropositive patients may develop ocular disease or genital herpes as characteristic infectious outcomes. Moreover, the infectious nature of HSV is so complex that the available therapeutic options have been modified in certain ways to cure it. However, no permanent and highly effective cure has been discovered. This review generates insights into the available prophylactic and therapeutic interventions against HSV. A methodological research approach is used for study design and data complication. Only the latest data from publications are acquired to shed light on updated therapeutic approaches. These studies indicate that the current antiviral therapeutics can suppress the symptoms and control viral transmission up to a certain level, but cannot eradicate the natural HSV infection and latency outcomes. Most trials that have entered the clinical phase are made part of this review to understand what is new within the field. Some vaccination approaches are also discussed. Moreover, some novel therapeutic options that are currently in research annals are given due consideration for future development. The data can enable the scientific community to direct their efforts to fill the gaps that remain unfilled in terms of therapies for HSV. The need is to integrate scientific efforts to produce a proper cure against HSV to control the virus spread, resistance, and mutation in future disease management.https://www.mdpi.com/2076-393X/11/2/325herpes simplex virusHSV biology and infectiontherapeuticsantiviral agentsvaccinestherapies |
| spellingShingle | Shiza Malik Ranjit Sah Omar Ahsan Khalid Muhammad Yasir Waheed Insights into the Novel Therapeutics and Vaccines against Herpes Simplex Virus Vaccines herpes simplex virus HSV biology and infection therapeutics antiviral agents vaccines therapies |
| title | Insights into the Novel Therapeutics and Vaccines against Herpes Simplex Virus |
| title_full | Insights into the Novel Therapeutics and Vaccines against Herpes Simplex Virus |
| title_fullStr | Insights into the Novel Therapeutics and Vaccines against Herpes Simplex Virus |
| title_full_unstemmed | Insights into the Novel Therapeutics and Vaccines against Herpes Simplex Virus |
| title_short | Insights into the Novel Therapeutics and Vaccines against Herpes Simplex Virus |
| title_sort | insights into the novel therapeutics and vaccines against herpes simplex virus |
| topic | herpes simplex virus HSV biology and infection therapeutics antiviral agents vaccines therapies |
| url | https://www.mdpi.com/2076-393X/11/2/325 |
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