The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of <italic toggle="yes">Vibrio cholerae</italic> Chromosome 2

The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of <italic toggle="yes">Vibrio cholerae</italic> Chromosome 2

ABSTRACT Replication of Vibrio cholerae chromosome 2 (Chr2) depends on molecular chaperone DnaK to facilitate binding of the initiator (RctB) to the replication origin. The binding occurs at two kinds of site, 12-mers and 39-mers, which promote and inhibit replication, respectively. Here we show tha...

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Bibliographic Details
Main Authors: Jyoti K. Jha, Mi Li, Rodolfo Ghirlando, Lisa M. Miller Jenkins, Alexander Wlodawer, Dhruba Chattoraj
Format: Article
Language:English
Published: American Society for Microbiology 2017-05-01
Series:mBio
Subjects:
chromosome replication
DNA-protein interactions
DnaK chaperone
initiator remodeling
initiator structure
Vibrio cholerae
Online Access:https://journals.asm.org/doi/10.1128/mBio.00427-17

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