Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports
Acquired von Willebrand disease (AvWD) represents a rare, potentially severe and most likely underdiagnosed category of hemorrhagic syndromes determined by quantitative, qualitative or functional, nonhereditary, alterations of von Willebrand factor (vWF) that occur in the context of various underlyi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-03-01
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| Series: | Romanian Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/rrlm-2016-0005 |
| _version_ | 1818609488703258624 |
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| author | Colită Andrei Saguna Carmen Costache Andra Borsaru Gabriela Manolache Raluca Ivănescu Ana Maria Lupu Anca Roxana |
| author_facet | Colită Andrei Saguna Carmen Costache Andra Borsaru Gabriela Manolache Raluca Ivănescu Ana Maria Lupu Anca Roxana |
| author_sort | Colită Andrei |
| collection | DOAJ |
| description | Acquired von Willebrand disease (AvWD) represents a rare, potentially severe and most likely underdiagnosed category of hemorrhagic syndromes determined by quantitative, qualitative or functional, nonhereditary, alterations of von Willebrand factor (vWF) that occur in the context of various underlying diseases. It is diagnosed mainly in adults, without any personal or familial history of bleeding. The etiopathogeny of AvWD is complex, marked by the intervention of multiple mechanisms, occuring in the evolution of neoplasia, autoimmune disorders, cardiovascular diseases and other conditions. The clinical and laboratory manifestations are similar to the congenital form with mucocutaneous hemorrhage in patients without bleeding history and demonstration of quantitative and/or functional anomalies of vWF. Treatment has two major objectives: control of bleeding and therapy of the underlying condition. As a practical illustration of the theoretical aspects we present 3 clinical cases of AvWD diagnosed in the Colţea Hospital Department of Hematology during the last 10 years. |
| first_indexed | 2024-12-16T14:59:20Z |
| format | Article |
| id | doaj.art-b5d9e0ab4f154a5f85bd630c7b1a7808 |
| institution | Directory Open Access Journal |
| issn | 2284-5623 |
| language | English |
| last_indexed | 2024-12-16T14:59:20Z |
| publishDate | 2016-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Laboratory Medicine |
| spelling | doaj.art-b5d9e0ab4f154a5f85bd630c7b1a78082022-12-21T22:27:21ZengSciendoRomanian Journal of Laboratory Medicine2284-56232016-03-012419310210.1515/rrlm-2016-0005rrlm-2016-0005Acquired von Willebrand disease: from theory to practice. A single center experience - three case reportsColită Andrei0Saguna Carmen1Costache Andra2Borsaru Gabriela3Manolache Raluca4Ivănescu Ana Maria5Lupu Anca Roxana61. University of Medicine and Pharmacy “Carol Davila”1. University of Medicine and Pharmacy “Carol Davila”1. University of Medicine and Pharmacy “Carol Davila”2. Coltea Hospital Bucharest, Romania2. Coltea Hospital Bucharest, Romania2. Coltea Hospital Bucharest, Romania1. University of Medicine and Pharmacy “Carol Davila”Acquired von Willebrand disease (AvWD) represents a rare, potentially severe and most likely underdiagnosed category of hemorrhagic syndromes determined by quantitative, qualitative or functional, nonhereditary, alterations of von Willebrand factor (vWF) that occur in the context of various underlying diseases. It is diagnosed mainly in adults, without any personal or familial history of bleeding. The etiopathogeny of AvWD is complex, marked by the intervention of multiple mechanisms, occuring in the evolution of neoplasia, autoimmune disorders, cardiovascular diseases and other conditions. The clinical and laboratory manifestations are similar to the congenital form with mucocutaneous hemorrhage in patients without bleeding history and demonstration of quantitative and/or functional anomalies of vWF. Treatment has two major objectives: control of bleeding and therapy of the underlying condition. As a practical illustration of the theoretical aspects we present 3 clinical cases of AvWD diagnosed in the Colţea Hospital Department of Hematology during the last 10 years.https://doi.org/10.1515/rrlm-2016-0005von willebrand disease acquired |
| spellingShingle | Colită Andrei Saguna Carmen Costache Andra Borsaru Gabriela Manolache Raluca Ivănescu Ana Maria Lupu Anca Roxana Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports Romanian Journal of Laboratory Medicine von willebrand disease acquired |
| title | Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports |
| title_full | Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports |
| title_fullStr | Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports |
| title_full_unstemmed | Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports |
| title_short | Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports |
| title_sort | acquired von willebrand disease from theory to practice a single center experience three case reports |
| topic | von willebrand disease acquired |
| url | https://doi.org/10.1515/rrlm-2016-0005 |
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