First-Trimester Maternal Vitamin D Levels and Risk for Gestational Diabetes Mellitus
INTRODUCTION: Vitamin D deficiency is linked to increased risk of adverse pregnancy outcomes, fetal and neonatal complications, as well as serious health consequences later in life for both mothers and offspring. However, studies on maternal vitamin D status and risk for gestational diabetes mellitu...
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| Format: | Article |
| Language: | English |
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Ankara Yildirim Beyazit University
2021-09-01
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| Series: | Ankara Medical Journal |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-60234 |
| _version_ | 1797907876564434944 |
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| author | Kağan Güngör Nur Dokuzeylül Güngör |
| author_facet | Kağan Güngör Nur Dokuzeylül Güngör |
| author_sort | Kağan Güngör |
| collection | DOAJ |
| description | INTRODUCTION: Vitamin D deficiency is linked to increased risk of adverse pregnancy outcomes, fetal and neonatal complications, as well as serious health consequences later in life for both mothers and offspring. However, studies on maternal vitamin D status and risk for gestational diabetes mellitus (GDM) are controversial. This study aimed to retrospectively evaluate the risk for GDM based on maternal serum vitamin D levels. METHODS: After applying the exclusion criteria, a total of 197 pregnant women, including 33 GDM cases and 164 controls, were enrolled in the study. Vitamin D levels were measured at 11–14 weeks of gestation. GDM was diagnosed by performing a 75-g oral glucose tolerance test between 24 and 28 weeks of gestation. RESULTS: BMI was higher in the GDM group than in the non-GDM group (24.68 [21.72–27.64] kg/m2 vs. 22.04 [20.51–24.73] kg/m2, p = 0.004). Vitamin D levels were significantly lower in the GDM group than in the non-GDM group (17.2 [15.6–19.2] nmol/L vs. 33.0 [31.2–35.0] nmol/L, p < 0.001). The prevalence of vitamin D deficiency was as high as 87.88% in the GDM group, with a 67.062-fold higher risk for GDM (odds ratio 67.062, 95% confidence interval 20.904–215.150, p < 0.001). DISCUSSION AND CONCLUSION: Insufficient vitamin D level in early pregnancy is significantly associated with GDM development. Routine screening for vitamin D deficiency during pregnancy, particularly at the first prenatal visit, may contribute to the identification and better management of GDM and its related adverse outcomes in mothers and offspring. |
| first_indexed | 2024-04-10T10:43:32Z |
| format | Article |
| id | doaj.art-b5da3c16c8314ee4a7c57bcc89e89be4 |
| institution | Directory Open Access Journal |
| issn | 2148-4570 |
| language | English |
| last_indexed | 2024-04-10T10:43:32Z |
| publishDate | 2021-09-01 |
| publisher | Ankara Yildirim Beyazit University |
| record_format | Article |
| series | Ankara Medical Journal |
| spelling | doaj.art-b5da3c16c8314ee4a7c57bcc89e89be42023-02-15T16:20:24ZengAnkara Yildirim Beyazit UniversityAnkara Medical Journal2148-45702021-09-0121333934910.5505/amj.2021.60234AMJ-60234First-Trimester Maternal Vitamin D Levels and Risk for Gestational Diabetes MellitusKağan Güngör0Nur Dokuzeylül Güngör1İstanbul Medeniyet University, Göztepe Training and Research Hospital, Department of Endocrinology and MetabolismBahçeşehir University Göztepe Medikal Park Hospital, Obstetrics and GynecologyINTRODUCTION: Vitamin D deficiency is linked to increased risk of adverse pregnancy outcomes, fetal and neonatal complications, as well as serious health consequences later in life for both mothers and offspring. However, studies on maternal vitamin D status and risk for gestational diabetes mellitus (GDM) are controversial. This study aimed to retrospectively evaluate the risk for GDM based on maternal serum vitamin D levels. METHODS: After applying the exclusion criteria, a total of 197 pregnant women, including 33 GDM cases and 164 controls, were enrolled in the study. Vitamin D levels were measured at 11–14 weeks of gestation. GDM was diagnosed by performing a 75-g oral glucose tolerance test between 24 and 28 weeks of gestation. RESULTS: BMI was higher in the GDM group than in the non-GDM group (24.68 [21.72–27.64] kg/m2 vs. 22.04 [20.51–24.73] kg/m2, p = 0.004). Vitamin D levels were significantly lower in the GDM group than in the non-GDM group (17.2 [15.6–19.2] nmol/L vs. 33.0 [31.2–35.0] nmol/L, p < 0.001). The prevalence of vitamin D deficiency was as high as 87.88% in the GDM group, with a 67.062-fold higher risk for GDM (odds ratio 67.062, 95% confidence interval 20.904–215.150, p < 0.001). DISCUSSION AND CONCLUSION: Insufficient vitamin D level in early pregnancy is significantly associated with GDM development. Routine screening for vitamin D deficiency during pregnancy, particularly at the first prenatal visit, may contribute to the identification and better management of GDM and its related adverse outcomes in mothers and offspring.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-60234gestational diabetes mellitusvitamin d deficiencypregnancyfirst trimester. |
| spellingShingle | Kağan Güngör Nur Dokuzeylül Güngör First-Trimester Maternal Vitamin D Levels and Risk for Gestational Diabetes Mellitus Ankara Medical Journal gestational diabetes mellitus vitamin d deficiency pregnancy first trimester. |
| title | First-Trimester Maternal Vitamin D Levels and Risk for Gestational Diabetes Mellitus |
| title_full | First-Trimester Maternal Vitamin D Levels and Risk for Gestational Diabetes Mellitus |
| title_fullStr | First-Trimester Maternal Vitamin D Levels and Risk for Gestational Diabetes Mellitus |
| title_full_unstemmed | First-Trimester Maternal Vitamin D Levels and Risk for Gestational Diabetes Mellitus |
| title_short | First-Trimester Maternal Vitamin D Levels and Risk for Gestational Diabetes Mellitus |
| title_sort | first trimester maternal vitamin d levels and risk for gestational diabetes mellitus |
| topic | gestational diabetes mellitus vitamin d deficiency pregnancy first trimester. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=amj&un=AMJ-60234 |
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