Advancements in fertility preservation strategies for pediatric male cancer patients: a review of cryopreservation and transplantation of immature testicular tissue
Abstract Recently, there has been increasing emphasis on the gonadotoxic effects of cancer therapy in prepubertal boys. As advances in oncology treatments continue to enhance survival rates for prepubertal boys, the need for preserving their functional testicular tissue for future reproduction becom...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12958-024-01219-5 |
| _version_ | 1827276858245251072 |
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| author | Zih-Yi Sung Yong-Qi Liao Jung-Hsiu Hou Hong-Hsien Lai Sung-Ming Weng Hai-Wei Jao Buo-Jia Lu Chi-Huang Chen |
| author_facet | Zih-Yi Sung Yong-Qi Liao Jung-Hsiu Hou Hong-Hsien Lai Sung-Ming Weng Hai-Wei Jao Buo-Jia Lu Chi-Huang Chen |
| author_sort | Zih-Yi Sung |
| collection | DOAJ |
| description | Abstract Recently, there has been increasing emphasis on the gonadotoxic effects of cancer therapy in prepubertal boys. As advances in oncology treatments continue to enhance survival rates for prepubertal boys, the need for preserving their functional testicular tissue for future reproduction becomes increasingly vital. Therefore, we explore cutting-edge strategies in fertility preservation, focusing on the cryopreservation and transplantation of immature testicular tissue as a promising avenue. The evolution of cryopreservation techniques, from controlled slow freezing to more recent advancements in vitrification, with an assessment of their strengths and limitations was exhibited. Detailed analysis of cryoprotectants, exposure times, and protocols underscores their impact on immature testicular tissue viability. In transplantation strategy, studies have revealed that the scrotal site may be the preferred location for immature testicular tissue grafting in both autotransplantation and xenotransplantation scenarios. Moreover, the use of biomaterial scaffolds during graft transplantation has shown promise in enhancing graft survival and stimulating spermatogenesis in immature testicular tissue over time. This comprehensive review provides a holistic approach to optimize the preservation strategy of human immature testicular tissue in the future. |
| first_indexed | 2024-04-24T07:11:07Z |
| format | Article |
| id | doaj.art-b5da9fdaa030498494023957b250f50e |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-04-24T07:11:07Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-b5da9fdaa030498494023957b250f50e2024-04-21T11:34:08ZengBMCReproductive Biology and Endocrinology1477-78272024-04-0122111510.1186/s12958-024-01219-5Advancements in fertility preservation strategies for pediatric male cancer patients: a review of cryopreservation and transplantation of immature testicular tissueZih-Yi Sung0Yong-Qi Liao1Jung-Hsiu Hou2Hong-Hsien Lai3Sung-Ming Weng4Hai-Wei Jao5Buo-Jia Lu6Chi-Huang Chen7School of Medicine, College of Medicine, Taipei Medical UniversitySchool of Medicine, College of Medicine, Taipei Medical UniversityGraduate Institute of Medical Science, College of Medicine, Taipei Medical UniversitySchool of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical UniversityDivision of Reproductive Medicine, Department of Obstetrics and Gynecology, Taipei Medical University HospitalDivision of Reproductive Medicine, Department of Obstetrics and Gynecology, Taipei Medical University HospitalDivision of Reproductive Medicine, Department of Obstetrics and Gynecology, Taipei Medical University HospitalAbstract Recently, there has been increasing emphasis on the gonadotoxic effects of cancer therapy in prepubertal boys. As advances in oncology treatments continue to enhance survival rates for prepubertal boys, the need for preserving their functional testicular tissue for future reproduction becomes increasingly vital. Therefore, we explore cutting-edge strategies in fertility preservation, focusing on the cryopreservation and transplantation of immature testicular tissue as a promising avenue. The evolution of cryopreservation techniques, from controlled slow freezing to more recent advancements in vitrification, with an assessment of their strengths and limitations was exhibited. Detailed analysis of cryoprotectants, exposure times, and protocols underscores their impact on immature testicular tissue viability. In transplantation strategy, studies have revealed that the scrotal site may be the preferred location for immature testicular tissue grafting in both autotransplantation and xenotransplantation scenarios. Moreover, the use of biomaterial scaffolds during graft transplantation has shown promise in enhancing graft survival and stimulating spermatogenesis in immature testicular tissue over time. This comprehensive review provides a holistic approach to optimize the preservation strategy of human immature testicular tissue in the future.https://doi.org/10.1186/s12958-024-01219-5Immature testicular tissueCryopreservationVitrificationSlow freezingCryoprotectantTissue engineering |
| spellingShingle | Zih-Yi Sung Yong-Qi Liao Jung-Hsiu Hou Hong-Hsien Lai Sung-Ming Weng Hai-Wei Jao Buo-Jia Lu Chi-Huang Chen Advancements in fertility preservation strategies for pediatric male cancer patients: a review of cryopreservation and transplantation of immature testicular tissue Reproductive Biology and Endocrinology Immature testicular tissue Cryopreservation Vitrification Slow freezing Cryoprotectant Tissue engineering |
| title | Advancements in fertility preservation strategies for pediatric male cancer patients: a review of cryopreservation and transplantation of immature testicular tissue |
| title_full | Advancements in fertility preservation strategies for pediatric male cancer patients: a review of cryopreservation and transplantation of immature testicular tissue |
| title_fullStr | Advancements in fertility preservation strategies for pediatric male cancer patients: a review of cryopreservation and transplantation of immature testicular tissue |
| title_full_unstemmed | Advancements in fertility preservation strategies for pediatric male cancer patients: a review of cryopreservation and transplantation of immature testicular tissue |
| title_short | Advancements in fertility preservation strategies for pediatric male cancer patients: a review of cryopreservation and transplantation of immature testicular tissue |
| title_sort | advancements in fertility preservation strategies for pediatric male cancer patients a review of cryopreservation and transplantation of immature testicular tissue |
| topic | Immature testicular tissue Cryopreservation Vitrification Slow freezing Cryoprotectant Tissue engineering |
| url | https://doi.org/10.1186/s12958-024-01219-5 |
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