A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes
Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes ind...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.896179/full |
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| author | Snehaa V. Seal Snehaa V. Seal Mathilde Henry Clémentine Pajot Cyrielle Holuka Cyrielle Holuka Danielle Bailbé Jamileh Movassat Muriel Darnaudéry Jonathan D. Turner |
| author_facet | Snehaa V. Seal Snehaa V. Seal Mathilde Henry Clémentine Pajot Cyrielle Holuka Cyrielle Holuka Danielle Bailbé Jamileh Movassat Muriel Darnaudéry Jonathan D. Turner |
| author_sort | Snehaa V. Seal |
| collection | DOAJ |
| description | Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats. |
| first_indexed | 2024-04-13T21:04:02Z |
| format | Article |
| id | doaj.art-b5db86067215415687966f5d0b7fcb70 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T21:04:02Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b5db86067215415687966f5d0b7fcb702022-12-22T02:30:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.896179896179A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 DiabetesSnehaa V. Seal0Snehaa V. Seal1Mathilde Henry2Clémentine Pajot3Cyrielle Holuka4Cyrielle Holuka5Danielle Bailbé6Jamileh Movassat7Muriel Darnaudéry8Jonathan D. Turner9Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, LuxembourgFaculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, LuxembourgInstitut National de Recherche Pour l'agriculture, l'alimentation et l'environnement (INRAE), Bordeaux Institut National Polytechnique (INP), NutriNeuro, Unité Mixte de Recherche (UMR) 1286, University of Bordeaux, Bordeaux, FranceInstitut National de Recherche Pour l'agriculture, l'alimentation et l'environnement (INRAE), Bordeaux Institut National Polytechnique (INP), NutriNeuro, Unité Mixte de Recherche (UMR) 1286, University of Bordeaux, Bordeaux, FranceDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, LuxembourgFaculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, LuxembourgUniversité de Paris, Laboratoire B2PE (Biologie et Pathologie du Pancréas Endocrine), Unité BFA (Biologie Fonctionnelle et Adaptative), Centre National de la Recherche Scientifique -Unité Mixte de Recherche (CNRS UMR) 8251, Paris, FranceUniversité de Paris, Laboratoire B2PE (Biologie et Pathologie du Pancréas Endocrine), Unité BFA (Biologie Fonctionnelle et Adaptative), Centre National de la Recherche Scientifique -Unité Mixte de Recherche (CNRS UMR) 8251, Paris, FranceInstitut National de Recherche Pour l'agriculture, l'alimentation et l'environnement (INRAE), Bordeaux Institut National Polytechnique (INP), NutriNeuro, Unité Mixte de Recherche (UMR) 1286, University of Bordeaux, Bordeaux, FranceDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, LuxembourgType-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats.https://www.frontiersin.org/articles/10.3389/fimmu.2022.896179/fulldiabetesobesitycytokinesinflammationmicroarraysGoto-Kakizaki rats |
| spellingShingle | Snehaa V. Seal Snehaa V. Seal Mathilde Henry Clémentine Pajot Cyrielle Holuka Cyrielle Holuka Danielle Bailbé Jamileh Movassat Muriel Darnaudéry Jonathan D. Turner A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes Frontiers in Immunology diabetes obesity cytokines inflammation microarrays Goto-Kakizaki rats |
| title | A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes |
| title_full | A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes |
| title_fullStr | A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes |
| title_full_unstemmed | A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes |
| title_short | A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes |
| title_sort | holistic view of the goto kakizaki rat immune system decreased circulating immune markers in non obese type 2 diabetes |
| topic | diabetes obesity cytokines inflammation microarrays Goto-Kakizaki rats |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.896179/full |
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