Development and Disorders of the Airway in Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD), a disorder characterized by arrested lung development, is a frequent cause of morbidity and mortality in premature infants. Parenchymal lung changes in BPD are relatively well-characterized and highly studied; however, there has been less emphasis placed on the role...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/7/1127 |
| _version_ | 1827733483996315648 |
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| author | Douglas Bush Courtney Juliano Selina Bowler Caterina Tiozzo |
| author_facet | Douglas Bush Courtney Juliano Selina Bowler Caterina Tiozzo |
| author_sort | Douglas Bush |
| collection | DOAJ |
| description | Bronchopulmonary dysplasia (BPD), a disorder characterized by arrested lung development, is a frequent cause of morbidity and mortality in premature infants. Parenchymal lung changes in BPD are relatively well-characterized and highly studied; however, there has been less emphasis placed on the role that airways disease plays in the pathophysiology of BPD. In preterm infants born between 22 and 32 weeks gestation, the conducting airways are fully formed but still immature and therefore susceptible to injury and further disruption of development. The arrest of maturation results in more compliant airways that are more susceptible to deformation and damage. Consequently, neonates with BPD are prone to developing airway pathology, particularly for patients who require intubation and positive-pressure ventilation. Airway pathology, which can be divided into large and small airways disease, results in increased respiratory morbidity in neonates with chronic lung disease of prematurity. |
| first_indexed | 2024-03-11T01:11:58Z |
| format | Article |
| id | doaj.art-b5db87ad7e6c4758b4b150478c546663 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T01:11:58Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-b5db87ad7e6c4758b4b150478c5466632023-11-18T18:48:34ZengMDPI AGChildren2227-90672023-06-01107112710.3390/children10071127Development and Disorders of the Airway in Bronchopulmonary DysplasiaDouglas Bush0Courtney Juliano1Selina Bowler2Caterina Tiozzo3Division of Pediatric Pulmonology, Department of Pediatrics, Mount Sinai Hospital, Icahn School of Medicine, New York, NY 10029, USADivision of Neonatology, Department of Pediatrics, Mount Sinai Hospital, Icahn School of Medicine, New York, NY 10029, USADepartment of Pediatrics, New York University Langone-Long Island, Mineola, NY 11501, USADivision of Neonatology, Department of Pediatrics, Mount Sinai Hospital, Icahn School of Medicine, New York, NY 10029, USABronchopulmonary dysplasia (BPD), a disorder characterized by arrested lung development, is a frequent cause of morbidity and mortality in premature infants. Parenchymal lung changes in BPD are relatively well-characterized and highly studied; however, there has been less emphasis placed on the role that airways disease plays in the pathophysiology of BPD. In preterm infants born between 22 and 32 weeks gestation, the conducting airways are fully formed but still immature and therefore susceptible to injury and further disruption of development. The arrest of maturation results in more compliant airways that are more susceptible to deformation and damage. Consequently, neonates with BPD are prone to developing airway pathology, particularly for patients who require intubation and positive-pressure ventilation. Airway pathology, which can be divided into large and small airways disease, results in increased respiratory morbidity in neonates with chronic lung disease of prematurity.https://www.mdpi.com/2227-9067/10/7/1127bronchopulmonary dysplasiaairway developmentairway disorders |
| spellingShingle | Douglas Bush Courtney Juliano Selina Bowler Caterina Tiozzo Development and Disorders of the Airway in Bronchopulmonary Dysplasia Children bronchopulmonary dysplasia airway development airway disorders |
| title | Development and Disorders of the Airway in Bronchopulmonary Dysplasia |
| title_full | Development and Disorders of the Airway in Bronchopulmonary Dysplasia |
| title_fullStr | Development and Disorders of the Airway in Bronchopulmonary Dysplasia |
| title_full_unstemmed | Development and Disorders of the Airway in Bronchopulmonary Dysplasia |
| title_short | Development and Disorders of the Airway in Bronchopulmonary Dysplasia |
| title_sort | development and disorders of the airway in bronchopulmonary dysplasia |
| topic | bronchopulmonary dysplasia airway development airway disorders |
| url | https://www.mdpi.com/2227-9067/10/7/1127 |
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