Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets
Abstract Perinatal hypoxic-ischemic brain injury of neonates remains a significant problem worldwide. During the resuscitation period, changes in cerebral hemoglobin oxygen saturation (ScO2) have been identified by near-infrared spectroscopy (NIRS). However, in asphyxiated neonates, the relationship...
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16625-1 |
| _version_ | 1811315430391808000 |
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| author | Yasuhiro Nakao Shinji Nakamura Yinmon Htun Tsutomu Mitsuie Kosuke Koyano Kenichi Ohta Yukihiko Konishi Takanori Miki Masaki Ueno Takashi Kusaka |
| author_facet | Yasuhiro Nakao Shinji Nakamura Yinmon Htun Tsutomu Mitsuie Kosuke Koyano Kenichi Ohta Yukihiko Konishi Takanori Miki Masaki Ueno Takashi Kusaka |
| author_sort | Yasuhiro Nakao |
| collection | DOAJ |
| description | Abstract Perinatal hypoxic-ischemic brain injury of neonates remains a significant problem worldwide. During the resuscitation period, changes in cerebral hemoglobin oxygen saturation (ScO2) have been identified by near-infrared spectroscopy (NIRS). However, in asphyxiated neonates, the relationship between these changes and brain injury is not known. Three-wavelength near-infrared time-resolved spectroscopy, an advanced technology for NIRS, allows for the estimation of ScO2 and cerebral blood volume (CBV). Here, we studied changes in ScO2 and CBV during the resuscitation period after hypoxic-ischemic insult and the relationship between these changes after insult and histopathological brain injuries on day 5 after insult using an asphyxiated piglet model. Of 36 newborn piglets subjected to hypoxic-ischemic insult, 29 were analyzed. ScO2 and CBV were measured 0, 5, 10, 15, and 30 min after the insult. Brain tissue was histologically evaluated on day 5. ScO2 and CBV increased immediately after the insult, reached a peak, and then maintained a consistent value. The increase in CBV 5 to 30 min after the insult was significantly correlated with histopathological injury scores. However, there was no correlation with ScO2. In conclusion, an increase in CBV within 30 min after hypoxic-ischemic insult reflects the histopathological brain injury on day 5 after insult in a piglet model. |
| first_indexed | 2024-04-13T11:30:02Z |
| format | Article |
| id | doaj.art-b5dc9182b53348659ff73fff39bb5ec2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T11:30:02Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b5dc9182b53348659ff73fff39bb5ec22022-12-22T02:48:35ZengNature PortfolioScientific Reports2045-23222022-08-0112111110.1038/s41598-022-16625-1Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn pigletsYasuhiro Nakao0Shinji Nakamura1Yinmon Htun2Tsutomu Mitsuie3Kosuke Koyano4Kenichi Ohta5Yukihiko Konishi6Takanori Miki7Masaki Ueno8Takashi Kusaka9Department of Pediatrics, Faculty of Medicine, Kagawa UniversityDepartment of Pediatrics, Faculty of Medicine, Kagawa UniversityDepartment of Pediatrics, Faculty of Medicine, Kagawa UniversityDepartment of Pediatrics, Faculty of Medicine, Kagawa UniversityMaternal Perinatal Center, Faculty of Medicine, Kagawa UniversityDepartment of Anatomy and Neurobiology, Faculty of Medicine, Kagawa UniversityDepartment of Pediatrics, Faculty of Medicine, Kagawa UniversityDepartment of Anatomy and Neurobiology, Faculty of Medicine, Kagawa UniversityDepartment of Pathology and Host Defense, Faculty of Medicine, Kagawa UniversityDepartment of Pediatrics, Faculty of Medicine, Kagawa UniversityAbstract Perinatal hypoxic-ischemic brain injury of neonates remains a significant problem worldwide. During the resuscitation period, changes in cerebral hemoglobin oxygen saturation (ScO2) have been identified by near-infrared spectroscopy (NIRS). However, in asphyxiated neonates, the relationship between these changes and brain injury is not known. Three-wavelength near-infrared time-resolved spectroscopy, an advanced technology for NIRS, allows for the estimation of ScO2 and cerebral blood volume (CBV). Here, we studied changes in ScO2 and CBV during the resuscitation period after hypoxic-ischemic insult and the relationship between these changes after insult and histopathological brain injuries on day 5 after insult using an asphyxiated piglet model. Of 36 newborn piglets subjected to hypoxic-ischemic insult, 29 were analyzed. ScO2 and CBV were measured 0, 5, 10, 15, and 30 min after the insult. Brain tissue was histologically evaluated on day 5. ScO2 and CBV increased immediately after the insult, reached a peak, and then maintained a consistent value. The increase in CBV 5 to 30 min after the insult was significantly correlated with histopathological injury scores. However, there was no correlation with ScO2. In conclusion, an increase in CBV within 30 min after hypoxic-ischemic insult reflects the histopathological brain injury on day 5 after insult in a piglet model.https://doi.org/10.1038/s41598-022-16625-1 |
| spellingShingle | Yasuhiro Nakao Shinji Nakamura Yinmon Htun Tsutomu Mitsuie Kosuke Koyano Kenichi Ohta Yukihiko Konishi Takanori Miki Masaki Ueno Takashi Kusaka Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets Scientific Reports |
| title | Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets |
| title_full | Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets |
| title_fullStr | Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets |
| title_full_unstemmed | Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets |
| title_short | Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets |
| title_sort | cerebral hemodynamic response during the resuscitation period after hypoxic ischemic insult predicts brain injury on day 5 after insult in newborn piglets |
| url | https://doi.org/10.1038/s41598-022-16625-1 |
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