The continuing discovery on the evidence for RNA editing in SARS-CoV-2
Recent studies have presented strong evidence that C-to-U RNA editing is the driving force that fuels severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution. The findings finally ended the long-term debate on the evolutionary driving force behind SARS-CoV-2 evolution. Here, we would...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | RNA Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15476286.2023.2214437 |
| _version_ | 1827595078459195392 |
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| author | Xiaoxin Pu Qinwei Xu Jinxiang Wang Baoyi Liu |
| author_facet | Xiaoxin Pu Qinwei Xu Jinxiang Wang Baoyi Liu |
| author_sort | Xiaoxin Pu |
| collection | DOAJ |
| description | Recent studies have presented strong evidence that C-to-U RNA editing is the driving force that fuels severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution. The findings finally ended the long-term debate on the evolutionary driving force behind SARS-CoV-2 evolution. Here, we would first acknowledge the breakthroughs made by the recent works, such as using the global SARS-CoV-2 data to demonstrate the major mutation source of this virus. Meanwhile, we would raise a few concerns on the accuracy of their interpretation on C-to-U RNA editing. By re-analysing the SARS-CoV-2 population data, we found that the editing frequency on C-to-U sites did not perfectly correlate with the binding motif of the editing enzyme APOBEC, suggesting that there might be false-positive sites among the C-to-U mutations or the original data did not fully represent the novel mutation rate. We hope our work could help people understand the molecular basis underlying SARS-CoV-2 mutation and also be useful to guide future studies on SARS-CoV-2 evolution. |
| first_indexed | 2024-03-09T02:46:35Z |
| format | Article |
| id | doaj.art-b5df0a67b6e54e489eb2dc7509227357 |
| institution | Directory Open Access Journal |
| issn | 1547-6286 1555-8584 |
| language | English |
| last_indexed | 2024-03-09T02:46:35Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj.art-b5df0a67b6e54e489eb2dc75092273572023-12-05T16:09:52ZengTaylor & Francis GroupRNA Biology1547-62861555-85842023-12-0120121922210.1080/15476286.2023.22144372214437The continuing discovery on the evidence for RNA editing in SARS-CoV-2Xiaoxin Pu0Qinwei Xu1Jinxiang Wang2Baoyi Liu3Shandong UniversityShandong UniversityShandong UniversityShandong UniversityRecent studies have presented strong evidence that C-to-U RNA editing is the driving force that fuels severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution. The findings finally ended the long-term debate on the evolutionary driving force behind SARS-CoV-2 evolution. Here, we would first acknowledge the breakthroughs made by the recent works, such as using the global SARS-CoV-2 data to demonstrate the major mutation source of this virus. Meanwhile, we would raise a few concerns on the accuracy of their interpretation on C-to-U RNA editing. By re-analysing the SARS-CoV-2 population data, we found that the editing frequency on C-to-U sites did not perfectly correlate with the binding motif of the editing enzyme APOBEC, suggesting that there might be false-positive sites among the C-to-U mutations or the original data did not fully represent the novel mutation rate. We hope our work could help people understand the molecular basis underlying SARS-CoV-2 mutation and also be useful to guide future studies on SARS-CoV-2 evolution.http://dx.doi.org/10.1080/15476286.2023.2214437evidencec-to-u rna editingsars-cov-2evolutionapobec motif |
| spellingShingle | Xiaoxin Pu Qinwei Xu Jinxiang Wang Baoyi Liu The continuing discovery on the evidence for RNA editing in SARS-CoV-2 RNA Biology evidence c-to-u rna editing sars-cov-2 evolution apobec motif |
| title | The continuing discovery on the evidence for RNA editing in SARS-CoV-2 |
| title_full | The continuing discovery on the evidence for RNA editing in SARS-CoV-2 |
| title_fullStr | The continuing discovery on the evidence for RNA editing in SARS-CoV-2 |
| title_full_unstemmed | The continuing discovery on the evidence for RNA editing in SARS-CoV-2 |
| title_short | The continuing discovery on the evidence for RNA editing in SARS-CoV-2 |
| title_sort | continuing discovery on the evidence for rna editing in sars cov 2 |
| topic | evidence c-to-u rna editing sars-cov-2 evolution apobec motif |
| url | http://dx.doi.org/10.1080/15476286.2023.2214437 |
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