Single-dose rAAV5-based vaccine provides long-term protective immunity against SARS-CoV-2 and its variants

Single-dose rAAV5-based vaccine provides long-term protective immunity against SARS-CoV-2 and its variants

Abstracts The COVID-19 pandemic, caused by the SARS-CoV-2 virus and its variants, has posed unprecedented challenges worldwide. Existing vaccines have limited effectiveness against SARS-CoV-2 variants. Therefore, novel vaccines to match mutated viral lineages by providing long-term protective immuni...

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Bibliographic Details
Main Authors: Guochao Liao, Hungyan Lau, Zhongqiu Liu, Chinyu Li, Zeping Xu, Xiaoxiao Qi, Yu Zhang, Qian Feng, Runze Li, Xinyu Deng, Yebo Li, Qing Zhu, Sisi Zhu, Hua Zhou, Hudan Pan, Xingxing Fan, Yongchao Li, Dan Li, Liqing Chen, Bixia Ke, Zhe Cong, Qi Lv, Jiangning Liu, Dan Liang, An’an Li, Wenshan Hong, Linlin Bao, Feng Zhou, Hongbin Gao, Shi Liang, Bihong Huang, Miaoli Wu, Chuan Qin, Changwen Ke, Liang Liu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Virology Journal
Subjects:
SARS-CoV-2
Vaccine
rAAV5
Neutralizing antibodies
Virus challenge
Online Access:https://doi.org/10.1186/s12985-022-01940-w

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