Temporal Changes in Pollen Concentration Predict Short‐Term Clinical Outcomes in Acute Coronary Syndromes
Background Atmospheric changes in pollen concentration may affect human health by triggering various allergic processes. We sought to assess if changes in pollen concentrations were associated with different acute coronary syndrome (ACS) subtype presentations and short‐term clinical outcomes. Method...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.023036 |
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| author | Omar Al‐Mukhtar Sara Vogrin Edwin R. Lampugnani Samer Noaman Diem T. Dinh Angela L. Brennan Christopher Reid Jeffrey Lefkovits Nicholas Cox Dion Stub William Chan |
| author_facet | Omar Al‐Mukhtar Sara Vogrin Edwin R. Lampugnani Samer Noaman Diem T. Dinh Angela L. Brennan Christopher Reid Jeffrey Lefkovits Nicholas Cox Dion Stub William Chan |
| author_sort | Omar Al‐Mukhtar |
| collection | DOAJ |
| description | Background Atmospheric changes in pollen concentration may affect human health by triggering various allergic processes. We sought to assess if changes in pollen concentrations were associated with different acute coronary syndrome (ACS) subtype presentations and short‐term clinical outcomes. Methods and Results We analyzed data in consecutive patients presenting with ACS (unstable angina, non–ST‐segment–elevation myocardial infarction, and ST‐segment–elevation myocardial infarction) treated with percutaneous coronary intervention between January 2014 and December 2017 and enrolled in the VCOR (Victorian Cardiac Outcomes Registry). Baseline characteristics were compared among patients exposed to different grass and total pollen concentrations. The primary outcome was occurrence of ACS subtypes and 30‐day major adverse cardiac and cerebrovascular events (composite of mortality, myocardial infarction, stent thrombosis, target vessel revascularization, or stroke). Of 15 379 patients, 7122 (46.3%) presented with ST‐segment–elevation myocardial infarction, 6781 (44.1%) with non–ST‐segment–elevation myocardial infarction, and 1476 (9.6%) with unstable angina. The mean age was 62.5 years, with men comprising 76% of patients. No association was observed between daily or seasonal grass and total pollen concentrations with the frequency of ACS subtype presentation. However, grass and total pollen concentrations in the preceding days (2‐day average for grass pollen and 7‐day average for total pollen) correlated with in‐hospital mortality (odds ratio [OR], 2.17 [95% CI, 1.12–4.21]; P=0.021 and OR, 2.78 [95% CI, 1.00–7.74]; P=0.05), respectively, with a trend of 2‐day grass pollen for 30‐day major adverse cardiac and cerebrovascular events (OR, 1.50 [95% CI, 0.97–2.32]; P=0.066). Conclusions Increased pollen concentrations were not associated with differential ACS subtype presentation but were significantly related to in‐hospital mortality following percutaneous coronary intervention, underscoring a potential biologic link between pollen exposure and clinical outcomes. |
| first_indexed | 2024-04-09T18:47:38Z |
| format | Article |
| id | doaj.art-b5dfbb6f681a4e27ad2cae5f018978f8 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-09T18:47:38Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-b5dfbb6f681a4e27ad2cae5f018978f82023-04-10T11:57:34ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-04-0111710.1161/JAHA.121.023036Temporal Changes in Pollen Concentration Predict Short‐Term Clinical Outcomes in Acute Coronary SyndromesOmar Al‐Mukhtar0Sara Vogrin1Edwin R. Lampugnani2Samer Noaman3Diem T. Dinh4Angela L. Brennan5Christopher Reid6Jeffrey Lefkovits7Nicholas Cox8Dion Stub9William Chan10Department of Cardiology Western Health Melbourne Victoria AustraliaDepartment of Medicine Western HealthMelbourne Medical SchoolUniversity of Melbourne Melbourne Victoria AustraliaSchool of Biosciences The University of Melbourne Melbourne Victoria AustraliaDepartment of Cardiology Western Health Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Melbourne Victoria AustraliaDepartment of Cardiology Western Health Melbourne Victoria AustraliaDepartment of Cardiology Western Health Melbourne Victoria AustraliaDepartment of Cardiology Western Health Melbourne Victoria AustraliaBackground Atmospheric changes in pollen concentration may affect human health by triggering various allergic processes. We sought to assess if changes in pollen concentrations were associated with different acute coronary syndrome (ACS) subtype presentations and short‐term clinical outcomes. Methods and Results We analyzed data in consecutive patients presenting with ACS (unstable angina, non–ST‐segment–elevation myocardial infarction, and ST‐segment–elevation myocardial infarction) treated with percutaneous coronary intervention between January 2014 and December 2017 and enrolled in the VCOR (Victorian Cardiac Outcomes Registry). Baseline characteristics were compared among patients exposed to different grass and total pollen concentrations. The primary outcome was occurrence of ACS subtypes and 30‐day major adverse cardiac and cerebrovascular events (composite of mortality, myocardial infarction, stent thrombosis, target vessel revascularization, or stroke). Of 15 379 patients, 7122 (46.3%) presented with ST‐segment–elevation myocardial infarction, 6781 (44.1%) with non–ST‐segment–elevation myocardial infarction, and 1476 (9.6%) with unstable angina. The mean age was 62.5 years, with men comprising 76% of patients. No association was observed between daily or seasonal grass and total pollen concentrations with the frequency of ACS subtype presentation. However, grass and total pollen concentrations in the preceding days (2‐day average for grass pollen and 7‐day average for total pollen) correlated with in‐hospital mortality (odds ratio [OR], 2.17 [95% CI, 1.12–4.21]; P=0.021 and OR, 2.78 [95% CI, 1.00–7.74]; P=0.05), respectively, with a trend of 2‐day grass pollen for 30‐day major adverse cardiac and cerebrovascular events (OR, 1.50 [95% CI, 0.97–2.32]; P=0.066). Conclusions Increased pollen concentrations were not associated with differential ACS subtype presentation but were significantly related to in‐hospital mortality following percutaneous coronary intervention, underscoring a potential biologic link between pollen exposure and clinical outcomes.https://www.ahajournals.org/doi/10.1161/JAHA.121.023036acute coronary syndromeenvironmentpollen count |
| spellingShingle | Omar Al‐Mukhtar Sara Vogrin Edwin R. Lampugnani Samer Noaman Diem T. Dinh Angela L. Brennan Christopher Reid Jeffrey Lefkovits Nicholas Cox Dion Stub William Chan Temporal Changes in Pollen Concentration Predict Short‐Term Clinical Outcomes in Acute Coronary Syndromes Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease acute coronary syndrome environment pollen count |
| title | Temporal Changes in Pollen Concentration Predict Short‐Term Clinical Outcomes in Acute Coronary Syndromes |
| title_full | Temporal Changes in Pollen Concentration Predict Short‐Term Clinical Outcomes in Acute Coronary Syndromes |
| title_fullStr | Temporal Changes in Pollen Concentration Predict Short‐Term Clinical Outcomes in Acute Coronary Syndromes |
| title_full_unstemmed | Temporal Changes in Pollen Concentration Predict Short‐Term Clinical Outcomes in Acute Coronary Syndromes |
| title_short | Temporal Changes in Pollen Concentration Predict Short‐Term Clinical Outcomes in Acute Coronary Syndromes |
| title_sort | temporal changes in pollen concentration predict short term clinical outcomes in acute coronary syndromes |
| topic | acute coronary syndrome environment pollen count |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.023036 |
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