Engineering receptors in the secretory pathway for orthogonal signalling control
Artificial receptors targeted to the secretory pathway often fail to exhibit the expected activity due to post-translational modifications and/or improper folding. Here, the authors engineer diverse synthetic receptors that reside in the cytoplasm, inside the endoplasmic reticulum, or on the plasma...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35161-0 |
| _version_ | 1811190424990121984 |
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| author | Mohamed Mahameed Pengli Wang Shuai Xue Martin Fussenegger |
| author_facet | Mohamed Mahameed Pengli Wang Shuai Xue Martin Fussenegger |
| author_sort | Mohamed Mahameed |
| collection | DOAJ |
| description | Artificial receptors targeted to the secretory pathway often fail to exhibit the expected activity due to post-translational modifications and/or improper folding. Here, the authors engineer diverse synthetic receptors that reside in the cytoplasm, inside the endoplasmic reticulum, or on the plasma membrane through orientation adjustment of the receptor parts and by elimination of dysfunctional PTMs sites. |
| first_indexed | 2024-04-11T14:50:07Z |
| format | Article |
| id | doaj.art-b5e0c34f72b74c65acf4b6b9dd8dc190 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T14:50:07Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b5e0c34f72b74c65acf4b6b9dd8dc1902022-12-22T04:17:31ZengNature PortfolioNature Communications2041-17232022-11-0113111510.1038/s41467-022-35161-0Engineering receptors in the secretory pathway for orthogonal signalling controlMohamed Mahameed0Pengli Wang1Shuai Xue2Martin Fussenegger3Department of Biosystems Science and Engineering, ETH ZurichDepartment of Biosystems Science and Engineering, ETH ZurichDepartment of Biosystems Science and Engineering, ETH ZurichDepartment of Biosystems Science and Engineering, ETH ZurichArtificial receptors targeted to the secretory pathway often fail to exhibit the expected activity due to post-translational modifications and/or improper folding. Here, the authors engineer diverse synthetic receptors that reside in the cytoplasm, inside the endoplasmic reticulum, or on the plasma membrane through orientation adjustment of the receptor parts and by elimination of dysfunctional PTMs sites.https://doi.org/10.1038/s41467-022-35161-0 |
| spellingShingle | Mohamed Mahameed Pengli Wang Shuai Xue Martin Fussenegger Engineering receptors in the secretory pathway for orthogonal signalling control Nature Communications |
| title | Engineering receptors in the secretory pathway for orthogonal signalling control |
| title_full | Engineering receptors in the secretory pathway for orthogonal signalling control |
| title_fullStr | Engineering receptors in the secretory pathway for orthogonal signalling control |
| title_full_unstemmed | Engineering receptors in the secretory pathway for orthogonal signalling control |
| title_short | Engineering receptors in the secretory pathway for orthogonal signalling control |
| title_sort | engineering receptors in the secretory pathway for orthogonal signalling control |
| url | https://doi.org/10.1038/s41467-022-35161-0 |
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