Molecular determinants of phase separation for Drosophila DNA replication licensing factors

Molecular determinants of phase separation for Drosophila DNA replication licensing factors

Liquid–liquid phase separation (LLPS) of intrinsically disordered regions (IDRs) in proteins can drive the formation of membraneless compartments in cells. Phase-separated structures enrich for specific partner proteins and exclude others. Previously, we showed that the IDRs of metazoan DNA replicat...

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Bibliographic Details
Main Authors:	Matthew W Parker, Jonchee A Kao, Alvin Huang, James M Berger, Michael R Botchan
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2021-12-01
Series:	eLife
Subjects:	DNA replication liquid phase condensates intrinsically disordered proteins DNA binding proteins
Online Access:	https://elifesciences.org/articles/70535

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