Fusion imaging-guided radiofrequency ablation for residual hepatocellular carcinoma invisible on ultrasound after transcatheter arterial chemoembolization
Purpose This study aimed to investigate the technical efficiency and therapeutic response of fusion imaging (considered as virtual navigation) between contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography/magnetic resonance imaging (CECT/CEMRI) for the guidance of radiofreque...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | http://dx.doi.org/10.1080/02656736.2021.1943545 |
| _version_ | 1819319841530576896 |
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| author | Jiong-Hui Gu Qi-Yu Zhao Chang He Zheng-Du Ye Min Xu Tian-An Jiang |
| author_facet | Jiong-Hui Gu Qi-Yu Zhao Chang He Zheng-Du Ye Min Xu Tian-An Jiang |
| author_sort | Jiong-Hui Gu |
| collection | DOAJ |
| description | Purpose This study aimed to investigate the technical efficiency and therapeutic response of fusion imaging (considered as virtual navigation) between contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography/magnetic resonance imaging (CECT/CEMRI) for the guidance of radiofrequency ablation (RFA) in patients with residual hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Methods For this prospective study, 98 patients with residual HCC lesions after TACE treatment were enrolled between June 2017 and December 2020. All the lesions were invisible on conventional ultrasound scans. Percutaneous RFA was performed using either CEUS (CEUS group, 52 lesions) or virtual navigation (VN group, 46 lesions) guidance. The lesion display rate, disease-free survival rate, local recurrence rate, overall survival rate and complication incidence were calculated and compared. Results Fusion imaging had a significant impact on the RFA outcomes (hazard ratio, 2.629; 95% confidence interval, 1.256–5.505; p = .01). The median disease-free survival time of the VN group was significantly higher than that of the CEUS group (10.9 vs. 8.8 months; p = .007). The local recurrence rates after 3, 6 and 12 months in the VN group were significantly lower than those in the CEUS group (p = .014, .002 and .011). The minor complication rate was not significantly different between the two groups. Conclusions CEUS–CECT/CEMRI fusion imaging for guiding RFA enables an efficient and useful therapy of inconspicuous HCC lesions after TACE. The novel solution prolongs the disease-free survival time and reduces the long-term local recurrence of residual lesions treated when using virtual-navigation (VN)-guided RFA. |
| first_indexed | 2024-12-24T11:10:06Z |
| format | Article |
| id | doaj.art-b5e76d35aa434108aec762edc47e05bf |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-24T11:10:06Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-b5e76d35aa434108aec762edc47e05bf2022-12-21T16:58:32ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572021-01-013811092109810.1080/02656736.2021.19435451943545Fusion imaging-guided radiofrequency ablation for residual hepatocellular carcinoma invisible on ultrasound after transcatheter arterial chemoembolizationJiong-Hui Gu0Qi-Yu Zhao1Chang He2Zheng-Du Ye3Min Xu4Tian-An Jiang5Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityPurpose This study aimed to investigate the technical efficiency and therapeutic response of fusion imaging (considered as virtual navigation) between contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography/magnetic resonance imaging (CECT/CEMRI) for the guidance of radiofrequency ablation (RFA) in patients with residual hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Methods For this prospective study, 98 patients with residual HCC lesions after TACE treatment were enrolled between June 2017 and December 2020. All the lesions were invisible on conventional ultrasound scans. Percutaneous RFA was performed using either CEUS (CEUS group, 52 lesions) or virtual navigation (VN group, 46 lesions) guidance. The lesion display rate, disease-free survival rate, local recurrence rate, overall survival rate and complication incidence were calculated and compared. Results Fusion imaging had a significant impact on the RFA outcomes (hazard ratio, 2.629; 95% confidence interval, 1.256–5.505; p = .01). The median disease-free survival time of the VN group was significantly higher than that of the CEUS group (10.9 vs. 8.8 months; p = .007). The local recurrence rates after 3, 6 and 12 months in the VN group were significantly lower than those in the CEUS group (p = .014, .002 and .011). The minor complication rate was not significantly different between the two groups. Conclusions CEUS–CECT/CEMRI fusion imaging for guiding RFA enables an efficient and useful therapy of inconspicuous HCC lesions after TACE. The novel solution prolongs the disease-free survival time and reduces the long-term local recurrence of residual lesions treated when using virtual-navigation (VN)-guided RFA.http://dx.doi.org/10.1080/02656736.2021.1943545fusion imagingradiofrequency ablationtranscatheter arterial chemoembolizationhepatocellular carcinomacontrast-enhanced ultrasound |
| spellingShingle | Jiong-Hui Gu Qi-Yu Zhao Chang He Zheng-Du Ye Min Xu Tian-An Jiang Fusion imaging-guided radiofrequency ablation for residual hepatocellular carcinoma invisible on ultrasound after transcatheter arterial chemoembolization International Journal of Hyperthermia fusion imaging radiofrequency ablation transcatheter arterial chemoembolization hepatocellular carcinoma contrast-enhanced ultrasound |
| title | Fusion imaging-guided radiofrequency ablation for residual hepatocellular carcinoma invisible on ultrasound after transcatheter arterial chemoembolization |
| title_full | Fusion imaging-guided radiofrequency ablation for residual hepatocellular carcinoma invisible on ultrasound after transcatheter arterial chemoembolization |
| title_fullStr | Fusion imaging-guided radiofrequency ablation for residual hepatocellular carcinoma invisible on ultrasound after transcatheter arterial chemoembolization |
| title_full_unstemmed | Fusion imaging-guided radiofrequency ablation for residual hepatocellular carcinoma invisible on ultrasound after transcatheter arterial chemoembolization |
| title_short | Fusion imaging-guided radiofrequency ablation for residual hepatocellular carcinoma invisible on ultrasound after transcatheter arterial chemoembolization |
| title_sort | fusion imaging guided radiofrequency ablation for residual hepatocellular carcinoma invisible on ultrasound after transcatheter arterial chemoembolization |
| topic | fusion imaging radiofrequency ablation transcatheter arterial chemoembolization hepatocellular carcinoma contrast-enhanced ultrasound |
| url | http://dx.doi.org/10.1080/02656736.2021.1943545 |
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