A metabolically-stabilized phosphonate analog of lysophosphatidic acid attenuates collagen-induced arthritis.

A metabolically-stabilized phosphonate analog of lysophosphatidic acid attenuates collagen-induced arthritis.

Rheumatoid arthritis (RA) is a destructive arthropathy with systemic manifestations, characterized by chronic synovial inflammation. Under the influence of the pro-inflammatory milieu synovial fibroblasts (SFs), the main effector cells in disease pathogenesis become activated and hyperplastic while...

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Bibliographic Details
Main Authors: Ioanna Nikitopoulou, Eleanna Kaffe, Ioanna Sevastou, Ivi Sirioti, Martina Samiotaki, Damian Madan, Glenn D Prestwich, Vassilis Aidinis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3726599?pdf=render

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