Hybrid SPECT-CT for characterizing isolated vertebral lesions observed by bone scintigraphy: comparison with planar scintigraphy, SPECT, and CT
PURPOSEWe aimed to assess the role of single photon emission computed tomography-computed tomography (SPECT-CT) for characterizing isolated vertebral lesions observed by bone scintigraphy compared to planar scintigraphy, SPECT, and CT, and to evaluate the impact of SPECT-CT on patient management. MA...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2013-01-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/hybrid-spect-ct-for-characterizing-isolated-verteb/56787
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| _version_ | 1797691661466206208 |
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| author | Punit Sharma, Varun Singh Dhull, Rama Mohan Reddy, Chandrasekhar Bal, Sanjay Thulkar, Arun Malhotra, Rakesh Kumar |
| author_facet | Punit Sharma, Varun Singh Dhull, Rama Mohan Reddy, Chandrasekhar Bal, Sanjay Thulkar, Arun Malhotra, Rakesh Kumar |
| author_sort | Punit Sharma, |
| collection | DOAJ |
| description | PURPOSEWe aimed to assess the role of single photon emission computed tomography-computed tomography (SPECT-CT) for characterizing isolated vertebral lesions observed by bone scintigraphy compared to planar scintigraphy, SPECT, and CT, and to evaluate the impact of SPECT-CT on patient management. MATERIALS AND METHODSData from 99 patients (mean age, 52.4±18.9 years; females, 58.5%) with 108 isolated vertebral lesions visible on planar bone scintigraphy, who had undergone SPECT-CT of a selected volume, were retrospectively analyzed. Planar scintigraphy, SPECT, CT, and SPECT-CT images were independently evaluated in separate sessions to minimize recall bias. A scoring scale of 1 to 5 was used, with 1 being definitely metastatic, 2 most likely metastatic, 3 indeterminate, 4 most likely benign, and 5 definitely benign. Sensitivity, specificity, and predictive values were calculated; a score ≤3 was defined as metastatic. The areas under the receiver operating characteristic curve were calculated and compared. Clinical and imaging followup with or without histopathology were used as a reference standard. RESULTSAmong the 108 lesions, 49 were indeterminate on planar scintigraphy, 16 on SPECT, and one each on SPECT-CT and CT. SPECT-CT was superior to both planar scintigraphy (P < 0.001) and SPECT alone (P = 0.014), but not to CT (P = 0.302). CT was superior to planar scintigraphy (P < 0.001) but only slightly superior to SPECT (P = 0.063). SPECT-CT correctly characterized 96% of the indeterminate lesions observed by planar scintigraphy. SPECT-CT had an impact on the clinical management of 60.6% patients compared to planar scintigraphy and 18.1% compared to SPECT. CONCLUSIONSPECT-CT is better than planar scintigraphy and SPECT alone, but not CT alone, for characterizing equivocal vertebral lesions that are observed by bone scintigraphy, thus SPECT-CT can have a significant impact on patient management. |
| first_indexed | 2024-03-12T02:16:27Z |
| format | Article |
| id | doaj.art-b5eec1d5d32347338182217026273ba1 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:16:27Z |
| publishDate | 2013-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-b5eec1d5d32347338182217026273ba12023-09-06T08:54:32ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122013-01-01191334010.4261/1305-3825.DIR.5790-12.113049054Hybrid SPECT-CT for characterizing isolated vertebral lesions observed by bone scintigraphy: comparison with planar scintigraphy, SPECT, and CTPunit Sharma,0Varun Singh Dhull,1Rama Mohan Reddy,2Chandrasekhar Bal,3Sanjay Thulkar,4Arun Malhotra,5Rakesh Kumar6 Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India. Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India. Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India. Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India. PURPOSEWe aimed to assess the role of single photon emission computed tomography-computed tomography (SPECT-CT) for characterizing isolated vertebral lesions observed by bone scintigraphy compared to planar scintigraphy, SPECT, and CT, and to evaluate the impact of SPECT-CT on patient management. MATERIALS AND METHODSData from 99 patients (mean age, 52.4±18.9 years; females, 58.5%) with 108 isolated vertebral lesions visible on planar bone scintigraphy, who had undergone SPECT-CT of a selected volume, were retrospectively analyzed. Planar scintigraphy, SPECT, CT, and SPECT-CT images were independently evaluated in separate sessions to minimize recall bias. A scoring scale of 1 to 5 was used, with 1 being definitely metastatic, 2 most likely metastatic, 3 indeterminate, 4 most likely benign, and 5 definitely benign. Sensitivity, specificity, and predictive values were calculated; a score ≤3 was defined as metastatic. The areas under the receiver operating characteristic curve were calculated and compared. Clinical and imaging followup with or without histopathology were used as a reference standard. RESULTSAmong the 108 lesions, 49 were indeterminate on planar scintigraphy, 16 on SPECT, and one each on SPECT-CT and CT. SPECT-CT was superior to both planar scintigraphy (P < 0.001) and SPECT alone (P = 0.014), but not to CT (P = 0.302). CT was superior to planar scintigraphy (P < 0.001) but only slightly superior to SPECT (P = 0.063). SPECT-CT correctly characterized 96% of the indeterminate lesions observed by planar scintigraphy. SPECT-CT had an impact on the clinical management of 60.6% patients compared to planar scintigraphy and 18.1% compared to SPECT. CONCLUSIONSPECT-CT is better than planar scintigraphy and SPECT alone, but not CT alone, for characterizing equivocal vertebral lesions that are observed by bone scintigraphy, thus SPECT-CT can have a significant impact on patient management. http://www.dirjournal.org/archives/archive-detail/article-preview/hybrid-spect-ct-for-characterizing-isolated-verteb/56787 |
| spellingShingle | Punit Sharma, Varun Singh Dhull, Rama Mohan Reddy, Chandrasekhar Bal, Sanjay Thulkar, Arun Malhotra, Rakesh Kumar Hybrid SPECT-CT for characterizing isolated vertebral lesions observed by bone scintigraphy: comparison with planar scintigraphy, SPECT, and CT Diagnostic and Interventional Radiology |
| title | Hybrid SPECT-CT for characterizing isolated vertebral lesions observed by bone scintigraphy: comparison with planar scintigraphy, SPECT, and CT |
| title_full | Hybrid SPECT-CT for characterizing isolated vertebral lesions observed by bone scintigraphy: comparison with planar scintigraphy, SPECT, and CT |
| title_fullStr | Hybrid SPECT-CT for characterizing isolated vertebral lesions observed by bone scintigraphy: comparison with planar scintigraphy, SPECT, and CT |
| title_full_unstemmed | Hybrid SPECT-CT for characterizing isolated vertebral lesions observed by bone scintigraphy: comparison with planar scintigraphy, SPECT, and CT |
| title_short | Hybrid SPECT-CT for characterizing isolated vertebral lesions observed by bone scintigraphy: comparison with planar scintigraphy, SPECT, and CT |
| title_sort | hybrid spect ct for characterizing isolated vertebral lesions observed by bone scintigraphy comparison with planar scintigraphy spect and ct |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/hybrid-spect-ct-for-characterizing-isolated-verteb/56787
|
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