Notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancer
Activation of Notch signaling pathway in cancer stem cells plays a crucial role in the regulation of selfrenewal and maintenance of side population cells. In the present study, we have identified cancer stem like 2.7% side population cells from nasopharyngeal carcinoma samples whose prevalence was...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2014-10-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/20342 |
| _version_ | 1818393584041197568 |
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| author | Guo-Fang Guan De-Jun Zhang Ding Xin Lian-Ji Wen Duo-Jiao Yu Yan-Qing Lu Yan Zhao Tie-Jun Wang |
| author_facet | Guo-Fang Guan De-Jun Zhang Ding Xin Lian-Ji Wen Duo-Jiao Yu Yan-Qing Lu Yan Zhao Tie-Jun Wang |
| author_sort | Guo-Fang Guan |
| collection | DOAJ |
| description | Activation of Notch signaling pathway in cancer stem cells plays a crucial role in the regulation of selfrenewal and maintenance of side population cells. In the present study, we have identified cancer stem like 2.7% side population cells from nasopharyngeal carcinoma samples whose prevalence was significantly reduced to 0.3% upon verapamil treatment. The protein level of Notch1 and Hes-1 are highly up-regulated in fluorescence-activated cell sorting purified side population cells and thus leads to the elevated expression of stem cell surface proteins (Oct-4, Sox2 and Nanog), which are essential for side population cells self-renewal. In addition, these nasopharyngeal carcinoma side population cells are CD133 and CD44 positive and they possess enhanced cell proliferation rate, highly tumorgenic and invasive. Our findings suggest that Notch1 signaling is a potential target of novel anticancer drugs, which could efficiently target and eradicate the cancer stem cells. |
| first_indexed | 2024-12-14T05:47:38Z |
| format | Article |
| id | doaj.art-b5ef6f6085a74d85b6bb5aeb57522915 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-14T05:47:38Z |
| publishDate | 2014-10-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-b5ef6f6085a74d85b6bb5aeb575229152022-12-21T23:14:49ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882014-10-0194Notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancerGuo-Fang Guan0De-Jun Zhang1Ding Xin2Lian-Ji Wen3Duo-Jiao Yu4Yan-Qing Lu5Yan Zhao6Tie-Jun Wang7Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041Department of Otolaryngology, Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130 041Department of Radiation Oncology, The Second Hospital of Jilin University, Changchun 130 041Activation of Notch signaling pathway in cancer stem cells plays a crucial role in the regulation of selfrenewal and maintenance of side population cells. In the present study, we have identified cancer stem like 2.7% side population cells from nasopharyngeal carcinoma samples whose prevalence was significantly reduced to 0.3% upon verapamil treatment. The protein level of Notch1 and Hes-1 are highly up-regulated in fluorescence-activated cell sorting purified side population cells and thus leads to the elevated expression of stem cell surface proteins (Oct-4, Sox2 and Nanog), which are essential for side population cells self-renewal. In addition, these nasopharyngeal carcinoma side population cells are CD133 and CD44 positive and they possess enhanced cell proliferation rate, highly tumorgenic and invasive. Our findings suggest that Notch1 signaling is a potential target of novel anticancer drugs, which could efficiently target and eradicate the cancer stem cells.https://www.banglajol.info/index.php/BJP/article/view/20342Anticancer drugAntiproliferative drugCancerStem cellVerapamil |
| spellingShingle | Guo-Fang Guan De-Jun Zhang Ding Xin Lian-Ji Wen Duo-Jiao Yu Yan-Qing Lu Yan Zhao Tie-Jun Wang Notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancer Bangladesh Journal of Pharmacology Anticancer drug Antiproliferative drug Cancer Stem cell Verapamil |
| title | Notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancer |
| title_full | Notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancer |
| title_fullStr | Notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancer |
| title_full_unstemmed | Notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancer |
| title_short | Notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancer |
| title_sort | notch 1 signaling pathway is the potential target of novel anticancer drugs for the treatment of human nasopharyngeal cancer |
| topic | Anticancer drug Antiproliferative drug Cancer Stem cell Verapamil |
| url | https://www.banglajol.info/index.php/BJP/article/view/20342 |
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