T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways

T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways

Objective: Beyond the taste buds, sweet taste receptors (STRs; T1R2/T1R3) are also expressed on enteroendocrine cells, where they regulate gut peptide secretion but their regulatory function within the intestine is largely unknown. Methods: Using T1R2-knock out (KO) mice we evaluated the role of STR...

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Main Authors: Kathleen Smith, Elnaz Karimian Azari, Traci E. LaMoia, Tania Hussain, Veronika Vargova, Katalin Karolyi, Paula P. Veldhuis, Juan Pablo Arnoletti, Sebastian G. de la Fuente, Richard E. Pratley, Timothy F. Osborne, George A. Kyriazis
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877818304988

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