Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only

Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only

IntroductionNeurogenesis within the dentate gyrus is thought to play an important role in cognitive processes such as reversal learning and pattern separation. The α7 nicotinic acetylcholine receptor (α7 nAChR) is expressed early in newly formed granule cells of the dentate gyrus, though its role in...

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Bibliographic Details
Main Authors: Ayland C. Letsinger, Samir A. Nacer, Korey D. Stevanovic, Gary J. Larson, Jemma S. DeFilipp, Jesse D. Cushman, Jerrel L. Yakel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Neuroscience
Subjects:
CHRNA7
acetylcholine
stereology
cognitive flexibility
touchscreen
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1244118/full

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