Advances in the study of hair follicle mesenchymal stem cells
Hair follicle mesenchymal stem cells (HFMSCs) are slow cycling label retaining cells with self-regeneration ability, high proliferative potential, and multi-directional differentiation. HFMSCs can induce and promote the regeneration of the epidermis, hair follicles and sebaceous glands. HFMSCs have...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2022-10-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.05.016 |
| _version_ | 1827855867318370304 |
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| author | Huijun LAI Lan YANG Furong YOU Pingping MA Hongwei GUO |
| author_facet | Huijun LAI Lan YANG Furong YOU Pingping MA Hongwei GUO |
| author_sort | Huijun LAI |
| collection | DOAJ |
| description | Hair follicle mesenchymal stem cells (HFMSCs) are slow cycling label retaining cells with self-regeneration ability, high proliferative potential, and multi-directional differentiation. HFMSCs can induce and promote the regeneration of the epidermis, hair follicles and sebaceous glands. HFMSCs have important advantages in regenerative medicine because of their abundance, wide availability, expansion in vitro, no genetic manipulation, no tumor formation and no ethical restriction. The synergy and antagonism between Wnt and other signaling pathways such as Shh, Notch and BMP signaling pathways play a crucial role in the regulation of stem cell homeostasis, epidermal development and hair follicle regeneration. The dysregulation of these pathways may result in hair loss diseases or skin tumors. This paper summarizes the classification and some specific biomarkers of HFMSCs, and discusses the induction of HFMSCs and the biomolecular pathways that affect hair regeneration, so as to shed light on the treatment strategies of hair diseases. |
| first_indexed | 2024-03-12T12:16:58Z |
| format | Article |
| id | doaj.art-b5f394f8a63c4fcd85890f53d9938a19 |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-03-12T12:16:58Z |
| publishDate | 2022-10-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-b5f394f8a63c4fcd85890f53d9938a192023-08-30T11:38:45Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682022-10-0129547247710.3969/j.issn.1674-8468.2022.05.016Advances in the study of hair follicle mesenchymal stem cellsHuijun LAI0Lan YANG1Furong YOU2Pingping MA3Hongwei GUO4Department of Dermatology, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang 524003, ChinaGuangdong Medical University, Zhanjiang 524023, ChinaGuangdong Medical University, Zhanjiang 524023, ChinaDepartment of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, ChinaDepartment of Dermatology, Second Affiliated Hospital of Guangdong Medical University, Zhanjiang 524003, ChinaHair follicle mesenchymal stem cells (HFMSCs) are slow cycling label retaining cells with self-regeneration ability, high proliferative potential, and multi-directional differentiation. HFMSCs can induce and promote the regeneration of the epidermis, hair follicles and sebaceous glands. HFMSCs have important advantages in regenerative medicine because of their abundance, wide availability, expansion in vitro, no genetic manipulation, no tumor formation and no ethical restriction. The synergy and antagonism between Wnt and other signaling pathways such as Shh, Notch and BMP signaling pathways play a crucial role in the regulation of stem cell homeostasis, epidermal development and hair follicle regeneration. The dysregulation of these pathways may result in hair loss diseases or skin tumors. This paper summarizes the classification and some specific biomarkers of HFMSCs, and discusses the induction of HFMSCs and the biomolecular pathways that affect hair regeneration, so as to shed light on the treatment strategies of hair diseases.http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.05.016hair follicle mesenchymal stem cellshair cyclehair follicle stem celldermal papilla cellshair regrowth |
| spellingShingle | Huijun LAI Lan YANG Furong YOU Pingping MA Hongwei GUO Advances in the study of hair follicle mesenchymal stem cells Pifu-xingbing zhenliaoxue zazhi hair follicle mesenchymal stem cells hair cycle hair follicle stem cell dermal papilla cells hair regrowth |
| title | Advances in the study of hair follicle mesenchymal stem cells |
| title_full | Advances in the study of hair follicle mesenchymal stem cells |
| title_fullStr | Advances in the study of hair follicle mesenchymal stem cells |
| title_full_unstemmed | Advances in the study of hair follicle mesenchymal stem cells |
| title_short | Advances in the study of hair follicle mesenchymal stem cells |
| title_sort | advances in the study of hair follicle mesenchymal stem cells |
| topic | hair follicle mesenchymal stem cells hair cycle hair follicle stem cell dermal papilla cells hair regrowth |
| url | http://pfxbzlx.gdvdc.com/CN/10.3969/j.issn.1674-8468.2022.05.016 |
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