Heat Shock Proteins in Behçet Syndrome
Behçet syndrome (BS) is a systemic vasculitis of unknown etiology that affects the skin, mucosa, joints, eyes, central nervous system, gastrointestinal system, arteries, and veins. It is generally believed to have a complex genetic background where both innate and adaptive immune systems are activat...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2023-09-01
|
| Series: | Balkan Medical Journal |
| Online Access: | https://www.balkanmedicaljournal.org/abstract.php?lang=en&id=2526 |
| _version_ | 1797687212197806080 |
|---|---|
| author | Aslı Kıymet Kireçtepe Aydın Gülen Hatemi |
| author_facet | Aslı Kıymet Kireçtepe Aydın Gülen Hatemi |
| author_sort | Aslı Kıymet Kireçtepe Aydın |
| collection | DOAJ |
| description | Behçet syndrome (BS) is a systemic vasculitis of unknown etiology that affects the skin, mucosa, joints, eyes, central nervous system, gastrointestinal system, arteries, and veins. It is generally believed to have a complex genetic background where both innate and adaptive immune systems are activated through environmental factors, such as infections, and auto-antigens. Heat shock proteins (HSPs) are highly conserved and immunogenic endogenous proteins that are thought to play both an enhancing and regulating role in several autoimmune and inflammatory diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, and Type I diabetes. There is evidence supporting the role of various microorganisms in BS, which may be using a common pathway to trigger or activate BS through molecular mimicry. The significant homology between microbial and human HSPs suggests that HSPs could serve as a common trigger. This review summarizes the work on the role of HSPs in the pathogenesis of BS. However, it remains unknown whether the HSPs detected in BS lesions play a causative role, their presence is a result of the ongoing inflammation, or they have a protective role against inflammation, as suggested in some other diseases. |
| first_indexed | 2024-03-12T01:15:57Z |
| format | Article |
| id | doaj.art-b5f4d493e303457d84f666833d246978 |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-03-12T01:15:57Z |
| publishDate | 2023-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-b5f4d493e303457d84f666833d2469782023-09-13T12:43:16ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312023-09-0140531432310.4274/balkanmedj.galenos.2023.2023-6-76Heat Shock Proteins in Behçet SyndromeAslı Kıymet Kireçtepe Aydın0https://orcid.org/0000-0001-8289-5191Gülen Hatemi1https://orcid.org/0000-0002-1952-1135Department of Medical Biology, İstanbul Nişantaşı University Medical Faculty, İstanbul, TurkeyDepartment of Internal Medicine, Division of Rheumatology, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul, TurkeyBehçet syndrome (BS) is a systemic vasculitis of unknown etiology that affects the skin, mucosa, joints, eyes, central nervous system, gastrointestinal system, arteries, and veins. It is generally believed to have a complex genetic background where both innate and adaptive immune systems are activated through environmental factors, such as infections, and auto-antigens. Heat shock proteins (HSPs) are highly conserved and immunogenic endogenous proteins that are thought to play both an enhancing and regulating role in several autoimmune and inflammatory diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, and Type I diabetes. There is evidence supporting the role of various microorganisms in BS, which may be using a common pathway to trigger or activate BS through molecular mimicry. The significant homology between microbial and human HSPs suggests that HSPs could serve as a common trigger. This review summarizes the work on the role of HSPs in the pathogenesis of BS. However, it remains unknown whether the HSPs detected in BS lesions play a causative role, their presence is a result of the ongoing inflammation, or they have a protective role against inflammation, as suggested in some other diseases.https://www.balkanmedicaljournal.org/abstract.php?lang=en&id=2526 |
| spellingShingle | Aslı Kıymet Kireçtepe Aydın Gülen Hatemi Heat Shock Proteins in Behçet Syndrome Balkan Medical Journal |
| title | Heat Shock Proteins in Behçet Syndrome |
| title_full | Heat Shock Proteins in Behçet Syndrome |
| title_fullStr | Heat Shock Proteins in Behçet Syndrome |
| title_full_unstemmed | Heat Shock Proteins in Behçet Syndrome |
| title_short | Heat Shock Proteins in Behçet Syndrome |
| title_sort | heat shock proteins in behcet syndrome |
| url | https://www.balkanmedicaljournal.org/abstract.php?lang=en&id=2526 |
| work_keys_str_mv | AT aslıkıymetkirectepeaydın heatshockproteinsinbehcetsyndrome AT gulenhatemi heatshockproteinsinbehcetsyndrome |