TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-β/Interferon-α/β Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model

TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-β/Interferon-α/β Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model

Acute pancreatitis (AP) is a common and devastating inflammatory disorder of the pancreas. However, there are still no effective treatments available for the disease. Therefore, it is important to discover new therapeutic targets and strategies for better treatment and prognosis of AP patients. Toll...

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Bibliographic Details
Main Authors: Chaohao Huang, Shengchuan Chen, Tan Zhang, Dapei Li, Zhonglin Huang, Jian Huang, Yanghua Qin, Bicheng Chen, Genhong Cheng, Feng Ma, Mengtao Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
acute pancreatitis
TLR3 ligands
polyI:C
reactive oxygen species
type I interferon
IFN-β
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00980/full

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