Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions
Abstract Background The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment approaches in this patient cohort, which we aim to address in this wor...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-11-01
|
| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-019-1406-x |
| _version_ | 1818267177262776320 |
|---|---|
| author | Thomas Held Paul Windisch Sati Akbaba Kristin Lang Benjamin Farnia Jakob Liermann Denise Bernhardt Peter Plinkert Christian Freudlsperger Stefan Rieken Klaus Herfarth Jürgen Debus Sebastian Adeberg |
| author_facet | Thomas Held Paul Windisch Sati Akbaba Kristin Lang Benjamin Farnia Jakob Liermann Denise Bernhardt Peter Plinkert Christian Freudlsperger Stefan Rieken Klaus Herfarth Jürgen Debus Sebastian Adeberg |
| author_sort | Thomas Held |
| collection | DOAJ |
| description | Abstract Background The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment approaches in this patient cohort, which we aim to address in this work. Methods Thirty-two (n = 32) consecutive patients with uncommon HNC treated between 2010 and 2017 were retrospectively analyzed in terms of clinical outcomes, patterns of failure, and toxicity. Results Mucoepidermoid carcinoma (MEC) was the most common histology (22%). Patients received a median cumulative dose equivalent in 2 Gy fractions (EQD2) after CIR of 128.6 Gy (range, 105.8–146.5 Gy). The local and distant control rates 1 year after CIR were 66 and 72%. No serious acute or late toxicity (≥ grade 3) after CIR was observed. Conclusions CIR may represent an effective and safe treatment alternative to palliative systemic therapies in these rare indications. |
| first_indexed | 2024-12-12T20:18:27Z |
| format | Article |
| id | doaj.art-b5f90db4cb2b4356afc32bf2f2d039e2 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-12T20:18:27Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-b5f90db4cb2b4356afc32bf2f2d039e22022-12-22T00:13:19ZengBMCRadiation Oncology1748-717X2019-11-011411710.1186/s13014-019-1406-xRare entities in head-and-neck cancer: salvage re-irradiation with carbon ionsThomas Held0Paul Windisch1Sati Akbaba2Kristin Lang3Benjamin Farnia4Jakob Liermann5Denise Bernhardt6Peter Plinkert7Christian Freudlsperger8Stefan Rieken9Klaus Herfarth10Jürgen Debus11Sebastian Adeberg12Department of Radiation Oncology, Heidelberg University HospitalDepartment of Radiation Oncology, Heidelberg University HospitalDepartment of Radiation Oncology, Heidelberg University HospitalDepartment of Radiation Oncology, Heidelberg University HospitalDepartment of Radiation Oncology, University of MiamiDepartment of Radiation Oncology, Heidelberg University HospitalDepartment of Radiation Oncology, Heidelberg University HospitalDepartment of Otorhinolaryngology, University of HeidelbergDepartment of Oral and Maxillofacial Surgery, University Hospital HeidelbergDepartment of Radiation Oncology, Heidelberg University HospitalDepartment of Radiation Oncology, Heidelberg University HospitalDepartment of Radiation Oncology, Heidelberg University HospitalDepartment of Radiation Oncology, Heidelberg University HospitalAbstract Background The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment approaches in this patient cohort, which we aim to address in this work. Methods Thirty-two (n = 32) consecutive patients with uncommon HNC treated between 2010 and 2017 were retrospectively analyzed in terms of clinical outcomes, patterns of failure, and toxicity. Results Mucoepidermoid carcinoma (MEC) was the most common histology (22%). Patients received a median cumulative dose equivalent in 2 Gy fractions (EQD2) after CIR of 128.6 Gy (range, 105.8–146.5 Gy). The local and distant control rates 1 year after CIR were 66 and 72%. No serious acute or late toxicity (≥ grade 3) after CIR was observed. Conclusions CIR may represent an effective and safe treatment alternative to palliative systemic therapies in these rare indications.http://link.springer.com/article/10.1186/s13014-019-1406-xSalvage re-irradiationHead and neck cancerCarbon ionsMucoepidermoid carcinomaParticle therapy |
| spellingShingle | Thomas Held Paul Windisch Sati Akbaba Kristin Lang Benjamin Farnia Jakob Liermann Denise Bernhardt Peter Plinkert Christian Freudlsperger Stefan Rieken Klaus Herfarth Jürgen Debus Sebastian Adeberg Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions Radiation Oncology Salvage re-irradiation Head and neck cancer Carbon ions Mucoepidermoid carcinoma Particle therapy |
| title | Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions |
| title_full | Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions |
| title_fullStr | Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions |
| title_full_unstemmed | Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions |
| title_short | Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions |
| title_sort | rare entities in head and neck cancer salvage re irradiation with carbon ions |
| topic | Salvage re-irradiation Head and neck cancer Carbon ions Mucoepidermoid carcinoma Particle therapy |
| url | http://link.springer.com/article/10.1186/s13014-019-1406-x |
| work_keys_str_mv | AT thomasheld rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT paulwindisch rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT satiakbaba rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT kristinlang rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT benjaminfarnia rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT jakobliermann rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT denisebernhardt rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT peterplinkert rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT christianfreudlsperger rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT stefanrieken rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT klausherfarth rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT jurgendebus rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions AT sebastianadeberg rareentitiesinheadandneckcancersalvagereirradiationwithcarbonions |