Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia
Neointimal hyperplasia is a complex process after vascular interventions, acute platelet deposition and smooth muscle cell proliferation both contributed to this process. There are still no perfect solutions to solve this problem. Rivaroxaban is a novel anticoagulant that has been widely used in cli...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Drug Delivery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2022.2092240 |
| _version_ | 1818218867353190400 |
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| author | Peng Sun Haoliang Wu Hao He Liwei Zhang Yuanfeng Liu Cong Zhang Chunyang Lou Jingan Li Hualong Bai |
| author_facet | Peng Sun Haoliang Wu Hao He Liwei Zhang Yuanfeng Liu Cong Zhang Chunyang Lou Jingan Li Hualong Bai |
| author_sort | Peng Sun |
| collection | DOAJ |
| description | Neointimal hyperplasia is a complex process after vascular interventions, acute platelet deposition and smooth muscle cell proliferation both contributed to this process. There are still no perfect solutions to solve this problem. Rivaroxaban is a novel anticoagulant that has been widely used in clinic, it has a good pharmacological effects both in vivo and in vitro. Chitosan microparticle rapamycin (MP-rapa) was fabricated, interspaces of polyglycolic acid (PGA) scaffold were used as a reservoir of MP-rapa, and the scaffold was coated with hyaluronic acid rivaroxaban (MP-rapa-riva). Scanning electronic microscopy (SEM) photographs were taken and water contact angles were measured, rat inferior vena cava (IVC) patch venoplasty model was used; patches were harvested at day 14 and examined by immunohistochemistry and immunofluorescence. SEM photographs showed the microparticles rapamycin were inside the interspace of the scaffold, hyaluronic acid rivaroxaban was also successfully coated onto the surface of the scaffold. There was a thinner neointima, fewer proliferating cell nuclear antigen (PCNA) positive cells, fewer macrophages in the MP-rapa and MP-rapa-riva grafts compared to the control PGA graft. The result showed that this scaffold with dual anticoagulation and antiproliferation functions can effectively inhibit venous neointimal hyperplasia, although this is an animal experiment, it showed promising potential clinical application in the future. |
| first_indexed | 2024-12-12T07:30:35Z |
| format | Article |
| id | doaj.art-b5fb3eff5dfe4f6092f9765919293055 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-12T07:30:35Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-b5fb3eff5dfe4f6092f97659192930552022-12-22T00:33:01ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642022-12-012911994200110.1080/10717544.2022.2092240Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasiaPeng Sun0Haoliang Wu1Hao He2Liwei Zhang3Yuanfeng Liu4Cong Zhang5Chunyang Lou6Jingan Li7Hualong Bai8Department of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, ChinaDepartment of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, ChinaDepartment of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, ChinaDepartment of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, ChinaDepartment of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, ChinaDepartment of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, ChinaSchool of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy & Key Laboratory of materials processing and mold technology (Ministry of Education), Zhengzhou, Henan Province, ChinaDepartment of Vascular and Endovascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, ChinaNeointimal hyperplasia is a complex process after vascular interventions, acute platelet deposition and smooth muscle cell proliferation both contributed to this process. There are still no perfect solutions to solve this problem. Rivaroxaban is a novel anticoagulant that has been widely used in clinic, it has a good pharmacological effects both in vivo and in vitro. Chitosan microparticle rapamycin (MP-rapa) was fabricated, interspaces of polyglycolic acid (PGA) scaffold were used as a reservoir of MP-rapa, and the scaffold was coated with hyaluronic acid rivaroxaban (MP-rapa-riva). Scanning electronic microscopy (SEM) photographs were taken and water contact angles were measured, rat inferior vena cava (IVC) patch venoplasty model was used; patches were harvested at day 14 and examined by immunohistochemistry and immunofluorescence. SEM photographs showed the microparticles rapamycin were inside the interspace of the scaffold, hyaluronic acid rivaroxaban was also successfully coated onto the surface of the scaffold. There was a thinner neointima, fewer proliferating cell nuclear antigen (PCNA) positive cells, fewer macrophages in the MP-rapa and MP-rapa-riva grafts compared to the control PGA graft. The result showed that this scaffold with dual anticoagulation and antiproliferation functions can effectively inhibit venous neointimal hyperplasia, although this is an animal experiment, it showed promising potential clinical application in the future.https://www.tandfonline.com/doi/10.1080/10717544.2022.2092240Neointimal hyperplasiarivaroxabanrapamycinchitosan microparticlepolyglycolic acid |
| spellingShingle | Peng Sun Haoliang Wu Hao He Liwei Zhang Yuanfeng Liu Cong Zhang Chunyang Lou Jingan Li Hualong Bai Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia Drug Delivery Neointimal hyperplasia rivaroxaban rapamycin chitosan microparticle polyglycolic acid |
| title | Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia |
| title_full | Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia |
| title_fullStr | Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia |
| title_full_unstemmed | Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia |
| title_short | Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia |
| title_sort | delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia |
| topic | Neointimal hyperplasia rivaroxaban rapamycin chitosan microparticle polyglycolic acid |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2022.2092240 |
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