A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue
Muscle fatigue and cognitive disturbances persist in patients after recovery from acute COVID-19 disease. However, there are no specific treatments for post-COVID fatigue. Objective: To evaluate the efficacy and safety of the health supplements ImmunoSEB (systemic enzyme complex) and ProbioSEB CSC3...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Medicines |
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| Online Access: | https://www.mdpi.com/2305-6320/8/9/47 |
| _version_ | 1797518325564047360 |
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| author | Abhijit Rathi Swati B. Jadhav Neha Shah |
| author_facet | Abhijit Rathi Swati B. Jadhav Neha Shah |
| author_sort | Abhijit Rathi |
| collection | DOAJ |
| description | Muscle fatigue and cognitive disturbances persist in patients after recovery from acute COVID-19 disease. However, there are no specific treatments for post-COVID fatigue. Objective: To evaluate the efficacy and safety of the health supplements ImmunoSEB (systemic enzyme complex) and ProbioSEB CSC3 (probiotic complex) in patients suffering from COVID-19 induced fatigue. A randomized, multicentric, double blind, placebo-controlled trial was conducted in 200 patients with a complaint of post-COVID fatigue. The test arm (<i>n</i> = 100) received the oral supplements for 14 days and the control arm (<i>n</i> = 100) received a placebo. Treatment efficacy was compared using the Chalder Fatigue scale (CFQ-11), at various time points from days 1 to 14. The supplemental treatment resulted in resolution of fatigue in a greater percentage of subjects in the test vs. the control arm (91% vs. 15%) on day 14. Subjects in the test arm showed a significantly greater reduction in total as well as physical and mental fatigue scores at all time points vs. the control arm. The supplements were well tolerated with no adverse events reported. This study demonstrates that a 14 days supplementation of ImmunoSEB + ProbioSEB CSC3 resolves post-COVID-19 fatigue and can improve patients’ functional status and quality of life. |
| first_indexed | 2024-03-10T07:27:20Z |
| format | Article |
| id | doaj.art-b5fb78f20b1c4718b4a2f65ed96a74a7 |
| institution | Directory Open Access Journal |
| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-03-10T07:27:20Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicines |
| spelling | doaj.art-b5fb78f20b1c4718b4a2f65ed96a74a72023-11-22T14:09:32ZengMDPI AGMedicines2305-63202021-08-01894710.3390/medicines8090047A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID FatigueAbhijit Rathi0Swati B. Jadhav1Neha Shah2Food Application and Development Laboratory, Advanced Enzymes Technologies Ltd., Louiswadi, Thane 400604, IndiaFood Application and Development Laboratory, Advanced Enzymes Technologies Ltd., Louiswadi, Thane 400604, IndiaPulmonary Fibrosis Now, Chino, CA 91710, USAMuscle fatigue and cognitive disturbances persist in patients after recovery from acute COVID-19 disease. However, there are no specific treatments for post-COVID fatigue. Objective: To evaluate the efficacy and safety of the health supplements ImmunoSEB (systemic enzyme complex) and ProbioSEB CSC3 (probiotic complex) in patients suffering from COVID-19 induced fatigue. A randomized, multicentric, double blind, placebo-controlled trial was conducted in 200 patients with a complaint of post-COVID fatigue. The test arm (<i>n</i> = 100) received the oral supplements for 14 days and the control arm (<i>n</i> = 100) received a placebo. Treatment efficacy was compared using the Chalder Fatigue scale (CFQ-11), at various time points from days 1 to 14. The supplemental treatment resulted in resolution of fatigue in a greater percentage of subjects in the test vs. the control arm (91% vs. 15%) on day 14. Subjects in the test arm showed a significantly greater reduction in total as well as physical and mental fatigue scores at all time points vs. the control arm. The supplements were well tolerated with no adverse events reported. This study demonstrates that a 14 days supplementation of ImmunoSEB + ProbioSEB CSC3 resolves post-COVID-19 fatigue and can improve patients’ functional status and quality of life.https://www.mdpi.com/2305-6320/8/9/47SARS-CoV-2 infectionCOVID-19-induced fatiguechalder fatigue scalephysical fatiguemental fatigueImmunoSEB + ProbioSEB CSC3 |
| spellingShingle | Abhijit Rathi Swati B. Jadhav Neha Shah A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue Medicines SARS-CoV-2 infection COVID-19-induced fatigue chalder fatigue scale physical fatigue mental fatigue ImmunoSEB + ProbioSEB CSC3 |
| title | A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue |
| title_full | A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue |
| title_fullStr | A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue |
| title_full_unstemmed | A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue |
| title_short | A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue |
| title_sort | randomized controlled trial of the efficacy of systemic enzymes and probiotics in the resolution of post covid fatigue |
| topic | SARS-CoV-2 infection COVID-19-induced fatigue chalder fatigue scale physical fatigue mental fatigue ImmunoSEB + ProbioSEB CSC3 |
| url | https://www.mdpi.com/2305-6320/8/9/47 |
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