Increased expression of autophagy and Nrf2-dependent signaling pathway genes by new monophenolic antioxidants depends on their structure

Increased expression of autophagy and Nrf2-dependent signaling pathway genes by new monophenolic antioxidants depends on their structure

Under certain conditions, both activators and inhibitors of Nrf2-dependent signaling and autophagy can serve as potential agents for the prevention, treatment, and maintenance therapy of cancer, as well as overcoming chemoresistance. We are developing a panel of structurally related synthetic monoph...

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Bibliographic Details
Main Authors: S. E. Khrapov, P. M. Kozhin, M. V. Khrapova, A. E. Serykh, L. P. Romakh, V. S. Pavlov, A. V. Chechushkov, S. V. Kholshin, N. K. Zenkov, E. B. Menshchikova
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Siberian Branch Publishing House 2021-06-01
Series:Сибирский научный медицинский журнал
Subjects:
antioxidants
keap1/nrf2/are signaling system
nad(p)h:quinone oxidoreductase-1
nrf2
nqo1
lc3b
sqstm1
Online Access:https://sibmed.elpub.ru/jour/article/view/598

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