HBZ and its roles in HTLV-1 oncogenesis
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. H...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00247/full |
| _version_ | 1819173295966126080 |
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| author | Tiejun eZhao Masao eMatsuoka |
| author_facet | Tiejun eZhao Masao eMatsuoka |
| author_sort | Tiejun eZhao |
| collection | DOAJ |
| description | Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, while the tax gene is frequently inactivated by epigenetic modifications or deletion of the 5’LTR. HBZ gene promotes the proliferation of ATL cells through its mRNA form. Moreover, HBZ induces T-cell lymphoma and systemic inflammation in vivo. HBZ fulfills its functions mainly through regulating HTLV-1 5’LTR transcription and modulating a variety of cellular signaling pathways which are related with cell growth, immune response and T-cell differentiation. Taken together, the multiple functions of HBZ render its predominant function in leukemogenesis of ATL. |
| first_indexed | 2024-12-22T20:20:49Z |
| format | Article |
| id | doaj.art-b5ff3d44ac16472689f146a74e91eacf |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T20:20:49Z |
| publishDate | 2012-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-b5ff3d44ac16472689f146a74e91eacf2022-12-21T18:13:51ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2012-07-01310.3389/fmicb.2012.0024729498HBZ and its roles in HTLV-1 oncogenesisTiejun eZhao0Masao eMatsuoka1Zhejiang Normal UniversityInstitute for Virus Research, Kyoto UniversityHuman T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, while the tax gene is frequently inactivated by epigenetic modifications or deletion of the 5’LTR. HBZ gene promotes the proliferation of ATL cells through its mRNA form. Moreover, HBZ induces T-cell lymphoma and systemic inflammation in vivo. HBZ fulfills its functions mainly through regulating HTLV-1 5’LTR transcription and modulating a variety of cellular signaling pathways which are related with cell growth, immune response and T-cell differentiation. Taken together, the multiple functions of HBZ render its predominant function in leukemogenesis of ATL.http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00247/fullHTLV-1regulatory T cellstaxHBZviral oncogenesis |
| spellingShingle | Tiejun eZhao Masao eMatsuoka HBZ and its roles in HTLV-1 oncogenesis Frontiers in Microbiology HTLV-1 regulatory T cells tax HBZ viral oncogenesis |
| title | HBZ and its roles in HTLV-1 oncogenesis |
| title_full | HBZ and its roles in HTLV-1 oncogenesis |
| title_fullStr | HBZ and its roles in HTLV-1 oncogenesis |
| title_full_unstemmed | HBZ and its roles in HTLV-1 oncogenesis |
| title_short | HBZ and its roles in HTLV-1 oncogenesis |
| title_sort | hbz and its roles in htlv 1 oncogenesis |
| topic | HTLV-1 regulatory T cells tax HBZ viral oncogenesis |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00247/full |
| work_keys_str_mv | AT tiejunezhao hbzanditsrolesinhtlv1oncogenesis AT masaoematsuoka hbzanditsrolesinhtlv1oncogenesis |