Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model.

Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model.

The envelope glycoproteins (Envs) of HIV-1 continuously evolve in the host by random mutations and recombination events. The resulting diversity of Env variants circulating in the population and their continuing diversification process limit the efficacy of AIDS vaccines. We examined the historic ch...

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Bibliographic Details
Main Authors: Orlando DeLeon, Hagit Hodis, Yunxia O'Malley, Jacklyn Johnson, Hamid Salimi, Yinjie Zhai, Elizabeth Winter, Claire Remec, Noah Eichelberger, Brandon Van Cleave, Ramya Puliadi, Robert D Harrington, Jack T Stapleton, Hillel Haim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2001549

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