CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site.

CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site.

BACKGROUND: We previously showed that blood serum induced cytochrome P450 1A1 (CYP1A1) monooxygenase expression in vitro. OBJECTIVE: Our purpose was (i) to identify the molecular mechanism involved and (ii) to characterize the inducer compound(s) in serum involved at least in part. METHODS: Serum wa...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Pierre-Henri Villard, Fabrice Barlesi, Martine Armand, Thi-Mai-Anh Dao, Jean-Marc Pascussi, Francis Fouchier, Serge Champion, Claire Dufour, Christian Giniès, Ayman Khalil, Marie-Josephe Amiot, Yves Barra, Eric Seree
Format: Artikel
Sprache:English
Veröffentlicht: Public Library of Science (PLoS) 2011-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC3031628?pdf=render

Online

http://europepmc.org/articles/PMC3031628?pdf=render

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