Epithelial maturation and molecular biology of oral HPV
<p>Abstract</p> <p>Human papillomavirus (HPV) is widespread and can cause latent infection in basal cells, with low HPV DNA copy-number insufficient for transmission of infection; can cause subclinical infection that is active but without clinical signs; or can cause clinical infec...
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| Format: | Article |
| Language: | English |
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BMC
2009-11-01
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| Series: | Infectious Agents and Cancer |
| Online Access: | http://www.infectagentscancer.com/content/4/1/16 |
| _version_ | 1818995612088008704 |
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| author | Wood Neil H Khammissa Razia AG Feller Liviu Lemmer Johan |
| author_facet | Wood Neil H Khammissa Razia AG Feller Liviu Lemmer Johan |
| author_sort | Wood Neil H |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Human papillomavirus (HPV) is widespread and can cause latent infection in basal cells, with low HPV DNA copy-number insufficient for transmission of infection; can cause subclinical infection that is active but without clinical signs; or can cause clinical infection leading to benign, potentially malignant or malignant lesions. The HPV cycle is influenced by the stage of maturation of the infected keratinocytes, and the production of virions is restricted to the post-mitotic suprabasal epithelial cells where all the virus genes are expressed.</p> <p>Low-risk HPV genotypes are associated with the development of benign oral lesions, whereas high-risk HPV genotypes are implicated in the development of malignant epithelial neoplasms. The rôle of high-risk HPV as a causative agent in epithelial malignancy is different at different anatomical sites: it is almost invariably implicated in squamous cell carcinoma of the uterine cervix, fairly frequently implicated in squamous cell carcinoma of the oropharynx, and it is seldom implicated in squamous cell carcinoma of the mouth.</p> |
| first_indexed | 2024-12-20T21:16:36Z |
| format | Article |
| id | doaj.art-b604d7a01bbb4876933f34229711be0b |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-12-20T21:16:36Z |
| publishDate | 2009-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-b604d7a01bbb4876933f34229711be0b2022-12-21T19:26:25ZengBMCInfectious Agents and Cancer1750-93782009-11-01411610.1186/1750-9378-4-16Epithelial maturation and molecular biology of oral HPVWood Neil HKhammissa Razia AGFeller LiviuLemmer Johan<p>Abstract</p> <p>Human papillomavirus (HPV) is widespread and can cause latent infection in basal cells, with low HPV DNA copy-number insufficient for transmission of infection; can cause subclinical infection that is active but without clinical signs; or can cause clinical infection leading to benign, potentially malignant or malignant lesions. The HPV cycle is influenced by the stage of maturation of the infected keratinocytes, and the production of virions is restricted to the post-mitotic suprabasal epithelial cells where all the virus genes are expressed.</p> <p>Low-risk HPV genotypes are associated with the development of benign oral lesions, whereas high-risk HPV genotypes are implicated in the development of malignant epithelial neoplasms. The rôle of high-risk HPV as a causative agent in epithelial malignancy is different at different anatomical sites: it is almost invariably implicated in squamous cell carcinoma of the uterine cervix, fairly frequently implicated in squamous cell carcinoma of the oropharynx, and it is seldom implicated in squamous cell carcinoma of the mouth.</p>http://www.infectagentscancer.com/content/4/1/16 |
| spellingShingle | Wood Neil H Khammissa Razia AG Feller Liviu Lemmer Johan Epithelial maturation and molecular biology of oral HPV Infectious Agents and Cancer |
| title | Epithelial maturation and molecular biology of oral HPV |
| title_full | Epithelial maturation and molecular biology of oral HPV |
| title_fullStr | Epithelial maturation and molecular biology of oral HPV |
| title_full_unstemmed | Epithelial maturation and molecular biology of oral HPV |
| title_short | Epithelial maturation and molecular biology of oral HPV |
| title_sort | epithelial maturation and molecular biology of oral hpv |
| url | http://www.infectagentscancer.com/content/4/1/16 |
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