Cardiac Fibroblast-Specific Knockout of PGC-1α Accelerates AngII-Induced Cardiac Remodeling

Cardiac Fibroblast-Specific Knockout of PGC-1α Accelerates AngII-Induced Cardiac Remodeling

Cardiac remodeling consisted of ventricular hypertrophy and interstitial fibrosis is the pathological process of many heart diseases. Fibroblasts as one of the major cells in the myocardium regulate the balance of the generation and degeneration of collagen, and these cells transform toward myofibro...

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Bibliographic Details
Main Authors: Hong-jin Chen, Xiao-xi Pan, Li-li-qiang Ding, Cheng-chao Ruan, Ping-jin Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiac fibroblast
fibrosis
PGC-1α
cardiac remodeling
AngII
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.664626/full

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