Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta‐analysis
Abstract Background Diabetic foot ulcer (DFU) is one of the most serious diabetic complications. DFU is an open wound that usually occurs in the foot sole due to poor blood glucose control, peripheral neuropathy, and poor circulation. The human amniotic allograft membrane is a biological wound dress...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Foot and Ankle Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13047-022-00575-y |
| _version_ | 1797321313328562176 |
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| author | Yasmine Adel Mohammed Hossam Khaled Farouk Mohamed Ibrahim Gbreel Abdelrahman Mahmoud Ali Ali Ashraf Salah Anas Zakarya Nourelden Mohamed Mahmoud Abd‐El Gawad |
| author_facet | Yasmine Adel Mohammed Hossam Khaled Farouk Mohamed Ibrahim Gbreel Abdelrahman Mahmoud Ali Ali Ashraf Salah Anas Zakarya Nourelden Mohamed Mahmoud Abd‐El Gawad |
| author_sort | Yasmine Adel Mohammed |
| collection | DOAJ |
| description | Abstract Background Diabetic foot ulcer (DFU) is one of the most serious diabetic complications. DFU is an open wound that usually occurs in the foot sole due to poor blood glucose control, peripheral neuropathy, and poor circulation. The human amniotic allograft membrane is a biological wound dressing derived from the amniotic membrane. It contains amino acids, nutrients, cytokines, and growth factors that make the growth process easier. Objective To compare dehydrated human amnion and chorion allograft (DHACA) plus the standard of wound care (SOC) with the SOC alone. Methods We searched for randomized clinical trials (RCTs) on PubMed, Scopus, Cochrane, and Web of Science till April 2021 using relevant keywords. All search results were screened for eligibility. We extracted the data from the included trials and pooled them as mean difference (MD) or risk ratio (RR) with the 95% confidence interval (CI) using Review Manager software (ver. 5.4). Results The pooled effect estimate from 11 RCTs showed that DHACA was superior to SOC regarding the complete wound healing in both 6th and 12th week (RR = 3.78; 95% CI: [2.51, 5.70]; P < 0.00001) and (RR = 2.00; 95% CI: [1.67, 2.39], P < 0.00001 respectively). Also, the analysis favored the DHACA regarding the mean time to heal in the 12th‐week (MD = ‐12.07, 95%CI: [‐19.23, ‐4.91], P = 0.001). The wound size reduction was better with DHACA (MD = 1.18, 95%CI: [‐0,10, 2.26], P = 0.03). Conclusion Using DHACA with SOC is safer and more effective than using SOC alone for DFU patients. |
| first_indexed | 2024-03-08T04:56:46Z |
| format | Article |
| id | doaj.art-b60958e0e7a845dc88a0a7800ad56c8c |
| institution | Directory Open Access Journal |
| issn | 1757-1146 |
| language | English |
| last_indexed | 2024-03-08T04:56:46Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Foot and Ankle Research |
| spelling | doaj.art-b60958e0e7a845dc88a0a7800ad56c8c2024-02-07T15:15:31ZengWileyJournal of Foot and Ankle Research1757-11462022-01-01151n/an/a10.1186/s13047-022-00575-yHuman amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta‐analysisYasmine Adel Mohammed0Hossam Khaled Farouk1Mohamed Ibrahim Gbreel2Abdelrahman Mahmoud Ali3Ali Ashraf Salah4Anas Zakarya Nourelden5Mohamed Mahmoud Abd‐El Gawad6Faculty of MedicineAssiut University71631AssiutAssiut governorateEgyptInternational Medical Research Association (IMedRA)CairoEgyptInternational Medical Research Association (IMedRA)CairoEgyptInternational Medical Research Association (IMedRA)CairoEgyptInternational Medical Research Association (IMedRA)CairoEgyptInternational Medical Research Association (IMedRA)CairoEgyptInternational Medical Research Association (IMedRA)CairoEgyptAbstract Background Diabetic foot ulcer (DFU) is one of the most serious diabetic complications. DFU is an open wound that usually occurs in the foot sole due to poor blood glucose control, peripheral neuropathy, and poor circulation. The human amniotic allograft membrane is a biological wound dressing derived from the amniotic membrane. It contains amino acids, nutrients, cytokines, and growth factors that make the growth process easier. Objective To compare dehydrated human amnion and chorion allograft (DHACA) plus the standard of wound care (SOC) with the SOC alone. Methods We searched for randomized clinical trials (RCTs) on PubMed, Scopus, Cochrane, and Web of Science till April 2021 using relevant keywords. All search results were screened for eligibility. We extracted the data from the included trials and pooled them as mean difference (MD) or risk ratio (RR) with the 95% confidence interval (CI) using Review Manager software (ver. 5.4). Results The pooled effect estimate from 11 RCTs showed that DHACA was superior to SOC regarding the complete wound healing in both 6th and 12th week (RR = 3.78; 95% CI: [2.51, 5.70]; P < 0.00001) and (RR = 2.00; 95% CI: [1.67, 2.39], P < 0.00001 respectively). Also, the analysis favored the DHACA regarding the mean time to heal in the 12th‐week (MD = ‐12.07, 95%CI: [‐19.23, ‐4.91], P = 0.001). The wound size reduction was better with DHACA (MD = 1.18, 95%CI: [‐0,10, 2.26], P = 0.03). Conclusion Using DHACA with SOC is safer and more effective than using SOC alone for DFU patients.https://doi.org/10.1186/s13047-022-00575-yDiabetic foot ulcerHuman amnion membraneAmniotic allograftGrafixAmnioBandEpiFix |
| spellingShingle | Yasmine Adel Mohammed Hossam Khaled Farouk Mohamed Ibrahim Gbreel Abdelrahman Mahmoud Ali Ali Ashraf Salah Anas Zakarya Nourelden Mohamed Mahmoud Abd‐El Gawad Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta‐analysis Journal of Foot and Ankle Research Diabetic foot ulcer Human amnion membrane Amniotic allograft Grafix AmnioBand EpiFix |
| title | Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta‐analysis |
| title_full | Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta‐analysis |
| title_fullStr | Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta‐analysis |
| title_full_unstemmed | Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta‐analysis |
| title_short | Human amniotic membrane products for patients with diabetic foot ulcers. do they help? a systematic review and meta‐analysis |
| title_sort | human amniotic membrane products for patients with diabetic foot ulcers do they help a systematic review and meta analysis |
| topic | Diabetic foot ulcer Human amnion membrane Amniotic allograft Grafix AmnioBand EpiFix |
| url | https://doi.org/10.1186/s13047-022-00575-y |
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