A Comparison of Clinical Features, Pathology and Outcomes in Various Subtypes of Breast Cancer in Indian Women
Background: Breast cancer is often classified into subtypes using immunohistochemical markers. These subtypes have distinct biological behaviour. This study was conducted with the aim of estimating the distribution of various subtypes of breast cancer in Indian population based on immunohistoche...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6461/15253_CE(Ra1)_F(GH)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background: Breast cancer is often classified into subtypes
using immunohistochemical markers. These subtypes have
distinct biological behaviour. This study was conducted with the
aim of estimating the distribution of various subtypes of breast
cancer in Indian population based on immunohistochemistry
markers and to determine the clinical features, pathology and
outcomes of these subtypes of breast cancer.
Materials and Methods: A retrospective study was undertaken
and all patients of breast cancer over a 5 year period were
included. These patients were divided into 4 subgroups
depending on the presence or absence of immunohistochemical
markers: i) Luminal A (ER/PR+, Her 2 neu–); ii) Luminal B (ER/
PR+, Her 2 neu+); iii) Her 2 enriched (ER-/PR-, Her 2 neu+) and;
iv) Triple negative (ER-,PR-, Her2 neu-). Clinical and pathological
features and survival were compared between patients in the 4
subgroups.
Results: Luminal A subgroup had majority of patients (43.8%).
Patients in Luminal B, Her 2 enriched, and Triple negative
subgroups were 14.8%, 16.1% and 25.3%. Median follow-up
of patients was for 34 months. Luminal A subgroup patients
were more likely to be postmenopausal and have smaller and
lower grade (I/II) tumours with better survival (OS-91.06%).
Patients in the Triple negative subgroup were more likely to be
premenopausal (p-value 0.036, odds ratio 0.611, CI 0.394-0.949),
have larger and higher grade (III) tumours with worse overall
survival (OS-88.46%, odds ratio 1.32, 95%CI 0.602-2.39). Her 2
enriched group patients had bad prognostic features like larger
size of tumour and higher grade of tumour and worst survival
among all the subgroups (OS-85.07%, odds ratio 1.78, 95% CI
0.767-4.163). However, these outcomes were not statistically
significant for the subgroups.
Conclusion: A retrospective study was undertaken of breast
cancer patients in India, according to subtypes based on
immunohistochemistry. Luminal A had prognostic features and
survival which was better as compared to other subgroups
(Luminal B, Her 2 enriched and Triple negative). Incidence of
patients with Triple negative breast cancer was higher in the
premenopausal period. Patients with Her 2 enriched breast
cancer had the worst survival among all the subgroups. |
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| ISSN: | 2249-782X 0973-709X |