A Comparison of Clinical Features, Pathology and Outcomes in Various Subtypes of Breast Cancer in Indian Women
Background: Breast cancer is often classified into subtypes using immunohistochemical markers. These subtypes have distinct biological behaviour. This study was conducted with the aim of estimating the distribution of various subtypes of breast cancer in Indian population based on immunohistoche...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2015-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/6461/15253_CE(Ra1)_F(GH)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
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| author | Anupama Mane Khalid Ismail Khatib Sanjay P. Deshmukh Shona M. Nag S. P. Sane Bhushan P.Zade |
| author_facet | Anupama Mane Khalid Ismail Khatib Sanjay P. Deshmukh Shona M. Nag S. P. Sane Bhushan P.Zade |
| author_sort | Anupama Mane |
| collection | DOAJ |
| description | Background: Breast cancer is often classified into subtypes
using immunohistochemical markers. These subtypes have
distinct biological behaviour. This study was conducted with the
aim of estimating the distribution of various subtypes of breast
cancer in Indian population based on immunohistochemistry
markers and to determine the clinical features, pathology and
outcomes of these subtypes of breast cancer.
Materials and Methods: A retrospective study was undertaken
and all patients of breast cancer over a 5 year period were
included. These patients were divided into 4 subgroups
depending on the presence or absence of immunohistochemical
markers: i) Luminal A (ER/PR+, Her 2 neu–); ii) Luminal B (ER/
PR+, Her 2 neu+); iii) Her 2 enriched (ER-/PR-, Her 2 neu+) and;
iv) Triple negative (ER-,PR-, Her2 neu-). Clinical and pathological
features and survival were compared between patients in the 4
subgroups.
Results: Luminal A subgroup had majority of patients (43.8%).
Patients in Luminal B, Her 2 enriched, and Triple negative
subgroups were 14.8%, 16.1% and 25.3%. Median follow-up
of patients was for 34 months. Luminal A subgroup patients
were more likely to be postmenopausal and have smaller and
lower grade (I/II) tumours with better survival (OS-91.06%).
Patients in the Triple negative subgroup were more likely to be
premenopausal (p-value 0.036, odds ratio 0.611, CI 0.394-0.949),
have larger and higher grade (III) tumours with worse overall
survival (OS-88.46%, odds ratio 1.32, 95%CI 0.602-2.39). Her 2
enriched group patients had bad prognostic features like larger
size of tumour and higher grade of tumour and worst survival
among all the subgroups (OS-85.07%, odds ratio 1.78, 95% CI
0.767-4.163). However, these outcomes were not statistically
significant for the subgroups.
Conclusion: A retrospective study was undertaken of breast
cancer patients in India, according to subtypes based on
immunohistochemistry. Luminal A had prognostic features and
survival which was better as compared to other subgroups
(Luminal B, Her 2 enriched and Triple negative). Incidence of
patients with Triple negative breast cancer was higher in the
premenopausal period. Patients with Her 2 enriched breast
cancer had the worst survival among all the subgroups. |
| first_indexed | 2024-12-14T08:38:10Z |
| format | Article |
| id | doaj.art-b60baeb909c7469f8e5ae3935ef8bb65 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T08:38:10Z |
| publishDate | 2015-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-b60baeb909c7469f8e5ae3935ef8bb652022-12-21T23:09:22ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-09-0199PC01PC0410.7860/JCDR/2015/15253.6461A Comparison of Clinical Features, Pathology and Outcomes in Various Subtypes of Breast Cancer in Indian WomenAnupama Mane0Khalid Ismail Khatib1Sanjay P. Deshmukh2Shona M. Nag3S. P. Sane4Bhushan P.Zade5Consulting Breast Surgeon, Ruby Hall Clinic, 40, Sassoon Road, Pune, Maharashtra, India.Associate Professor, Department of Medicine, S. K. N. Medical College, Narhe, Pune, Maharashtra, India.Consulting OncoSurgeon, Ruby Hall Clinic, 40, Sassoon Road, Pune, Maharashtra, India.Consulting Medical Oncologist, Jehangir Hospital, Pune, Maharashtra, India.Consulting Surgeon, Ruby Hall Clinic, 40, Sassoon Road, Pune, Maharashtra, India.Consulting Radiation Oncologist, Ruby Hall Clinic, 40, Sassoon Road, Pune, Maharashtra, India.Background: Breast cancer is often classified into subtypes using immunohistochemical markers. These subtypes have distinct biological behaviour. This study was conducted with the aim of estimating the distribution of various subtypes of breast cancer in Indian population based on immunohistochemistry markers and to determine the clinical features, pathology and outcomes of these subtypes of breast cancer. Materials and Methods: A retrospective study was undertaken and all patients of breast cancer over a 5 year period were included. These patients were divided into 4 subgroups depending on the presence or absence of immunohistochemical markers: i) Luminal A (ER/PR+, Her 2 neu–); ii) Luminal B (ER/ PR+, Her 2 neu+); iii) Her 2 enriched (ER-/PR-, Her 2 neu+) and; iv) Triple negative (ER-,PR-, Her2 neu-). Clinical and pathological features and survival were compared between patients in the 4 subgroups. Results: Luminal A subgroup had majority of patients (43.8%). Patients in Luminal B, Her 2 enriched, and Triple negative subgroups were 14.8%, 16.1% and 25.3%. Median follow-up of patients was for 34 months. Luminal A subgroup patients were more likely to be postmenopausal and have smaller and lower grade (I/II) tumours with better survival (OS-91.06%). Patients in the Triple negative subgroup were more likely to be premenopausal (p-value 0.036, odds ratio 0.611, CI 0.394-0.949), have larger and higher grade (III) tumours with worse overall survival (OS-88.46%, odds ratio 1.32, 95%CI 0.602-2.39). Her 2 enriched group patients had bad prognostic features like larger size of tumour and higher grade of tumour and worst survival among all the subgroups (OS-85.07%, odds ratio 1.78, 95% CI 0.767-4.163). However, these outcomes were not statistically significant for the subgroups. Conclusion: A retrospective study was undertaken of breast cancer patients in India, according to subtypes based on immunohistochemistry. Luminal A had prognostic features and survival which was better as compared to other subgroups (Luminal B, Her 2 enriched and Triple negative). Incidence of patients with Triple negative breast cancer was higher in the premenopausal period. Patients with Her 2 enriched breast cancer had the worst survival among all the subgroups.https://jcdr.net/articles/PDF/6461/15253_CE(Ra1)_F(GH)_PF1(PAK)_PFA(AK)_PF2(PAG).pdfestrogen receptorher2immunohistochemistrytriple negative |
| spellingShingle | Anupama Mane Khalid Ismail Khatib Sanjay P. Deshmukh Shona M. Nag S. P. Sane Bhushan P.Zade A Comparison of Clinical Features, Pathology and Outcomes in Various Subtypes of Breast Cancer in Indian Women Journal of Clinical and Diagnostic Research estrogen receptor her2 immunohistochemistry triple negative |
| title | A Comparison of Clinical Features, Pathology and Outcomes in Various Subtypes of Breast Cancer in Indian Women |
| title_full | A Comparison of Clinical Features, Pathology and Outcomes in Various Subtypes of Breast Cancer in Indian Women |
| title_fullStr | A Comparison of Clinical Features, Pathology and Outcomes in Various Subtypes of Breast Cancer in Indian Women |
| title_full_unstemmed | A Comparison of Clinical Features, Pathology and Outcomes in Various Subtypes of Breast Cancer in Indian Women |
| title_short | A Comparison of Clinical Features, Pathology and Outcomes in Various Subtypes of Breast Cancer in Indian Women |
| title_sort | comparison of clinical features pathology and outcomes in various subtypes of breast cancer in indian women |
| topic | estrogen receptor her2 immunohistochemistry triple negative |
| url | https://jcdr.net/articles/PDF/6461/15253_CE(Ra1)_F(GH)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
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