D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study
Serum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 pati...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=12;spage=2014;epage=2020;aulast=Liu |
| _version_ | 1818280960132644864 |
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| author | Jun-hui Liu Xiang-kui Li Zhi-biao Chen Qiang Cai Long Wang Ying-hu Ye Qian-xue Chen |
| author_facet | Jun-hui Liu Xiang-kui Li Zhi-biao Chen Qiang Cai Long Wang Ying-hu Ye Qian-xue Chen |
| author_sort | Jun-hui Liu |
| collection | DOAJ |
| description | Serum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 patients with aneurysmal subarachnoid hemorrhage who were treated in Renmin Hospital of Wuhan University of China between 1 May 2014 and 30 March 2016. There were 57 males and 89 females included and average age of included patients was 57.03 years old. Serum samples were taken immediately on admission (within 48 hours after initial hemorrhage) and the levels of serum biomarkers were detected. Baseline information, complications, and outcomes at 6 months were recorded. Univariate and multivariate logistic regression analyses were used to explore the relationship between biomarkers and clinical outcomes. Receiver operating characteristic curves were obtained to investigate the possibility of the biomarkers predicting prognosis. Of the 146 patients, 102 patients achieved good outcomes and 44 patients had poor outcomes. Univariate and multivariate analyses showed that high World Federation of Neurosurgical Societies grade, high serum D-dimer levels, and high neurological complications were significantly associated with poor outcomes. Receiver operating characteristic curves verified that D-dimer levels were associated with poor outcomes. D-dimer levels strongly correlated with neurological complications. In conclusion, we suggest that D-dimer levels are a good independent prognostic factor for poor outcomes in patients with aneurysmal subarachnoid hemorrhage. |
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| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-12T23:57:31Z |
| publishDate | 2017-01-01 |
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| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-b60bcb00b2b64834a72fd2d464bcdbe72022-12-22T00:06:32ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-0112122014202010.4103/1673-5374.221158D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective studyJun-hui LiuXiang-kui LiZhi-biao ChenQiang CaiLong WangYing-hu YeQian-xue ChenSerum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 patients with aneurysmal subarachnoid hemorrhage who were treated in Renmin Hospital of Wuhan University of China between 1 May 2014 and 30 March 2016. There were 57 males and 89 females included and average age of included patients was 57.03 years old. Serum samples were taken immediately on admission (within 48 hours after initial hemorrhage) and the levels of serum biomarkers were detected. Baseline information, complications, and outcomes at 6 months were recorded. Univariate and multivariate logistic regression analyses were used to explore the relationship between biomarkers and clinical outcomes. Receiver operating characteristic curves were obtained to investigate the possibility of the biomarkers predicting prognosis. Of the 146 patients, 102 patients achieved good outcomes and 44 patients had poor outcomes. Univariate and multivariate analyses showed that high World Federation of Neurosurgical Societies grade, high serum D-dimer levels, and high neurological complications were significantly associated with poor outcomes. Receiver operating characteristic curves verified that D-dimer levels were associated with poor outcomes. D-dimer levels strongly correlated with neurological complications. In conclusion, we suggest that D-dimer levels are a good independent prognostic factor for poor outcomes in patients with aneurysmal subarachnoid hemorrhage.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=12;spage=2014;epage=2020;aulast=Liunerve regeneration; aneurysmal subarachnoid hemorrhage; D-dimer; serum; biomarkers; complications; prognosis; logistic regression analysis; neural regeneration |
| spellingShingle | Jun-hui Liu Xiang-kui Li Zhi-biao Chen Qiang Cai Long Wang Ying-hu Ye Qian-xue Chen D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study Neural Regeneration Research nerve regeneration; aneurysmal subarachnoid hemorrhage; D-dimer; serum; biomarkers; complications; prognosis; logistic regression analysis; neural regeneration |
| title | D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study |
| title_full | D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study |
| title_fullStr | D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study |
| title_full_unstemmed | D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study |
| title_short | D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study |
| title_sort | d dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage a retrospective study |
| topic | nerve regeneration; aneurysmal subarachnoid hemorrhage; D-dimer; serum; biomarkers; complications; prognosis; logistic regression analysis; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=12;spage=2014;epage=2020;aulast=Liu |
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