Association between pregnancy induced hypertension and maternal thyroid stimulating hormone levels - a hospital based observational case control study
Background: With rise in incidence of hypertensive disorders of pregnancy especially pre -eclampsia, there is a need to study its association with other comorbid conditions like thyroid disorder which may have common pathophysiology. Objective: The following case control study was done to know the a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Barpeta Obstetrics and Gynaecological Society
2022-02-01
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| Series: | New Indian Journal of OBGYN |
| Subjects: | |
| Online Access: | https://journal.barpetaogs.co.in/pdf/08227.pdf |
| _version_ | 1818205033901064192 |
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| author | Mahadevi Savanur Anubha Kataria Gauri Prabhu Nitin Sutariya |
| author_facet | Mahadevi Savanur Anubha Kataria Gauri Prabhu Nitin Sutariya |
| author_sort | Mahadevi Savanur |
| collection | DOAJ |
| description | Background: With rise in incidence of hypertensive disorders of pregnancy especially pre -eclampsia, there is a need to study its association with other comorbid conditions like thyroid disorder which may have common pathophysiology. Objective: The following case control study was done to know the association between pregnancy induced hypertension and serum thyroid stimulating hormone (TSH) level. Methodology: This case control study was carried out at tertiary care hospital from June 2018 to December 2018 wherein we compared mean TSH level among hypertensive pregnant women (case) and normotensive pregnant women (control) in third trimester. We also further analysed the differences of mean TSH level within hypertensive group based on severity. The total sample size consisted of 300 cases and 300 matched controls. Results: Mean serum TSH level was found significantly higher in the hypertensive (case) group i.e (2.81±2.08) as compared to the normotensive (control) group i.e (2.32 ±1.24) with p-value 0.0006. The association between pre-eclampsia and hypothyroidism was seen by odds ratio of 1.87 (CI= 1.06 - 3.27) for patients with severe pre-eclampsia, 1.41 (CI = 0.78 - 2.55) for patients with non severe pre-eclampsia and1.24 (CI = 0.66 - 2.33) for patients with gestational hypertension in comparison to the normotensive patients. Mean serum albumin was significantly lower in cases (3.22±0.43) as compared to control groups (3.30±0.38) with p-value 0.0122. However the correlation coefficient for the entire study population was (-0.0532) between serum albumin and serum TSH, which suggests both values were independent of each other. Serum uric acid was significantly higher in cases as compared to controls (p<0.0001). Conclusion: Biochemical hypothyroidism in pregnancy is associated with pre-eclampsia especially with severe pre-eclampsia. However Serum TSH values need to be adjusted to the population and hospital for cut offs for reliable diagnosis. |
| first_indexed | 2024-12-12T03:50:42Z |
| format | Article |
| id | doaj.art-b60e6059a2bc4f068c4aa0961381e6d1 |
| institution | Directory Open Access Journal |
| issn | 2454-2334 2454-2342 |
| language | English |
| last_indexed | 2024-12-12T03:50:42Z |
| publishDate | 2022-02-01 |
| publisher | Barpeta Obstetrics and Gynaecological Society |
| record_format | Article |
| series | New Indian Journal of OBGYN |
| spelling | doaj.art-b60e6059a2bc4f068c4aa0961381e6d12022-12-22T00:39:24ZengBarpeta Obstetrics and Gynaecological SocietyNew Indian Journal of OBGYN2454-23342454-23422022-02-018222723210.21276/obgyn.2022.8.2.14Association between pregnancy induced hypertension and maternal thyroid stimulating hormone levels - a hospital based observational case control studyMahadevi Savanur0Anubha Kataria 1Gauri Prabhu2Nitin Sutariya3Assistant Professor, Department of Obstetrics and Gynaecology, JNMC, KAHER, Belgavi, Karnataka, IndiaJunior Resident (Post Graduate Student), Department of Obstetrics and Gynaecology, The Oxford Medical College Hospital and Research Centre, Bengalore, IndiaAssistant Professor, Department of Obstetrics and Gynaecology, JNMC, KAHER, Belgavi, Karnataka, IndiaJunior Resident, Department of Obstetrics and Gynaecology, GMERD Medical college, Valsad, Gujarat, IndiaBackground: With rise in incidence of hypertensive disorders of pregnancy especially pre -eclampsia, there is a need to study its association with other comorbid conditions like thyroid disorder which may have common pathophysiology. Objective: The following case control study was done to know the association between pregnancy induced hypertension and serum thyroid stimulating hormone (TSH) level. Methodology: This case control study was carried out at tertiary care hospital from June 2018 to December 2018 wherein we compared mean TSH level among hypertensive pregnant women (case) and normotensive pregnant women (control) in third trimester. We also further analysed the differences of mean TSH level within hypertensive group based on severity. The total sample size consisted of 300 cases and 300 matched controls. Results: Mean serum TSH level was found significantly higher in the hypertensive (case) group i.e (2.81±2.08) as compared to the normotensive (control) group i.e (2.32 ±1.24) with p-value 0.0006. The association between pre-eclampsia and hypothyroidism was seen by odds ratio of 1.87 (CI= 1.06 - 3.27) for patients with severe pre-eclampsia, 1.41 (CI = 0.78 - 2.55) for patients with non severe pre-eclampsia and1.24 (CI = 0.66 - 2.33) for patients with gestational hypertension in comparison to the normotensive patients. Mean serum albumin was significantly lower in cases (3.22±0.43) as compared to control groups (3.30±0.38) with p-value 0.0122. However the correlation coefficient for the entire study population was (-0.0532) between serum albumin and serum TSH, which suggests both values were independent of each other. Serum uric acid was significantly higher in cases as compared to controls (p<0.0001). Conclusion: Biochemical hypothyroidism in pregnancy is associated with pre-eclampsia especially with severe pre-eclampsia. However Serum TSH values need to be adjusted to the population and hospital for cut offs for reliable diagnosis.https://journal.barpetaogs.co.in/pdf/08227.pdfhypothyroidismpreeclampsiathyroid stimulating hormone |
| spellingShingle | Mahadevi Savanur Anubha Kataria Gauri Prabhu Nitin Sutariya Association between pregnancy induced hypertension and maternal thyroid stimulating hormone levels - a hospital based observational case control study New Indian Journal of OBGYN hypothyroidism preeclampsia thyroid stimulating hormone |
| title | Association between pregnancy induced hypertension and maternal thyroid stimulating hormone levels - a hospital based observational case control study |
| title_full | Association between pregnancy induced hypertension and maternal thyroid stimulating hormone levels - a hospital based observational case control study |
| title_fullStr | Association between pregnancy induced hypertension and maternal thyroid stimulating hormone levels - a hospital based observational case control study |
| title_full_unstemmed | Association between pregnancy induced hypertension and maternal thyroid stimulating hormone levels - a hospital based observational case control study |
| title_short | Association between pregnancy induced hypertension and maternal thyroid stimulating hormone levels - a hospital based observational case control study |
| title_sort | association between pregnancy induced hypertension and maternal thyroid stimulating hormone levels a hospital based observational case control study |
| topic | hypothyroidism preeclampsia thyroid stimulating hormone |
| url | https://journal.barpetaogs.co.in/pdf/08227.pdf |
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