A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinetics and a sustained virological response in a chronic, monoinfected hepatitis C virus genotype-1 Brazilian population treated with pegylated interferon-ribavirin
Single nucleotide polymorphisms (SNPs) in the interleukin (IL)28B locus have been associated with a sustained virological response (SVR) in interferon-ribavirin (IFN-RBV)-treated chronic hepatitis C virus (HCV)-infected patients in European and African populations. In this study, the genotype freque...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2012-11-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000700008&lng=en&tlng=en |
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| author | Juliene Antonio Ramos Ana Lúcia de Araújo Ramos Luisa Hoffmann Renata de Mello Perez Henrique Sérgio Moraes Coelho Turán Péter Ürményi Rosane Silva Edson Rondinelli Cristiane Alves Villela-Nogueira |
| author_facet | Juliene Antonio Ramos Ana Lúcia de Araújo Ramos Luisa Hoffmann Renata de Mello Perez Henrique Sérgio Moraes Coelho Turán Péter Ürményi Rosane Silva Edson Rondinelli Cristiane Alves Villela-Nogueira |
| author_sort | Juliene Antonio Ramos |
| collection | DOAJ |
| description | Single nucleotide polymorphisms (SNPs) in the interleukin (IL)28B locus have been associated with a sustained virological response (SVR) in interferon-ribavirin (IFN-RBV)-treated chronic hepatitis C virus (HCV)-infected patients in European and African populations. In this study, the genotype frequency of two IL28B SNPs (rs129679860 and rs8099917) in a cohort of chronic HCV-monoinfected patients in Brazil was evaluated and the SNP sufficient to predict the treatment response outcome was determined. A total of 66 naïve genotype-1 chronic HCV-infected patients were genotyped and the associated viral kinetics and SVR were assessed. The overall SVR was 38%. Both the viral kinetics and SVR were associated with rs129679860 genotypes (CC = 62% vs. CT = 33% vs. TT = 18%, p = 0.016). However, rs8099917 genotypes were only associated with SVR (TT = 53% vs. TG = 33% vs. GG = 18%; p = 0.032). In this population, the analysis of a single SNP, rs12979860, successfully predicts SVR in the IFN-RBV treatment of HCV. |
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| id | doaj.art-b60e9b7fd5e04a3f85391e1285789777 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T09:30:32Z |
| publishDate | 2012-11-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-b60e9b7fd5e04a3f85391e12857897772023-09-02T13:54:24ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602012-11-01107788889210.1590/S0074-02762012000700008S0074-02762012000700008A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinetics and a sustained virological response in a chronic, monoinfected hepatitis C virus genotype-1 Brazilian population treated with pegylated interferon-ribavirinJuliene Antonio Ramos0Ana Lúcia de Araújo Ramos1Luisa Hoffmann2Renata de Mello Perez3Henrique Sérgio Moraes Coelho4Turán Péter Ürményi5Rosane Silva6Edson Rondinelli7Cristiane Alves Villela-Nogueira8Universidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroSingle nucleotide polymorphisms (SNPs) in the interleukin (IL)28B locus have been associated with a sustained virological response (SVR) in interferon-ribavirin (IFN-RBV)-treated chronic hepatitis C virus (HCV)-infected patients in European and African populations. In this study, the genotype frequency of two IL28B SNPs (rs129679860 and rs8099917) in a cohort of chronic HCV-monoinfected patients in Brazil was evaluated and the SNP sufficient to predict the treatment response outcome was determined. A total of 66 naïve genotype-1 chronic HCV-infected patients were genotyped and the associated viral kinetics and SVR were assessed. The overall SVR was 38%. Both the viral kinetics and SVR were associated with rs129679860 genotypes (CC = 62% vs. CT = 33% vs. TT = 18%, p = 0.016). However, rs8099917 genotypes were only associated with SVR (TT = 53% vs. TG = 33% vs. GG = 18%; p = 0.032). In this population, the analysis of a single SNP, rs12979860, successfully predicts SVR in the IFN-RBV treatment of HCV.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000700008&lng=en&tlng=enIL28Brs12979860rs8099917hepatitis Ctreatment |
| spellingShingle | Juliene Antonio Ramos Ana Lúcia de Araújo Ramos Luisa Hoffmann Renata de Mello Perez Henrique Sérgio Moraes Coelho Turán Péter Ürményi Rosane Silva Edson Rondinelli Cristiane Alves Villela-Nogueira A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinetics and a sustained virological response in a chronic, monoinfected hepatitis C virus genotype-1 Brazilian population treated with pegylated interferon-ribavirin Memorias do Instituto Oswaldo Cruz IL28B rs12979860 rs8099917 hepatitis C treatment |
| title | A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinetics and a sustained virological response in a chronic, monoinfected hepatitis C virus genotype-1 Brazilian population treated with pegylated interferon-ribavirin |
| title_full | A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinetics and a sustained virological response in a chronic, monoinfected hepatitis C virus genotype-1 Brazilian population treated with pegylated interferon-ribavirin |
| title_fullStr | A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinetics and a sustained virological response in a chronic, monoinfected hepatitis C virus genotype-1 Brazilian population treated with pegylated interferon-ribavirin |
| title_full_unstemmed | A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinetics and a sustained virological response in a chronic, monoinfected hepatitis C virus genotype-1 Brazilian population treated with pegylated interferon-ribavirin |
| title_short | A single nucleotide polymorphism, rs129679860, in the IL28B locus is associated with the viral kinetics and a sustained virological response in a chronic, monoinfected hepatitis C virus genotype-1 Brazilian population treated with pegylated interferon-ribavirin |
| title_sort | single nucleotide polymorphism rs129679860 in the il28b locus is associated with the viral kinetics and a sustained virological response in a chronic monoinfected hepatitis c virus genotype 1 brazilian population treated with pegylated interferon ribavirin |
| topic | IL28B rs12979860 rs8099917 hepatitis C treatment |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000700008&lng=en&tlng=en |
| work_keys_str_mv | AT julieneantonioramos asinglenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT analuciadearaujoramos asinglenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT luisahoffmann asinglenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT renatademelloperez asinglenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT henriquesergiomoraescoelho asinglenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT turanpeterurmenyi asinglenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT rosanesilva asinglenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT edsonrondinelli asinglenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT cristianealvesvillelanogueira asinglenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT julieneantonioramos singlenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT analuciadearaujoramos singlenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT luisahoffmann singlenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT renatademelloperez singlenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT henriquesergiomoraescoelho singlenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT turanpeterurmenyi singlenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT rosanesilva singlenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT edsonrondinelli singlenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin AT cristianealvesvillelanogueira singlenucleotidepolymorphismrs129679860intheil28blocusisassociatedwiththeviralkineticsandasustainedvirologicalresponseinachronicmonoinfectedhepatitiscvirusgenotype1brazilianpopulationtreatedwithpegylatedinterferonribavirin |