A Pilot Study: The Reduction in Fecal Acetate in Obese Patients after Probiotic Administration and Percutaneous Electrical Neurostimulation
Previous data suggested that anti-obesity interventions, such as percutaneous electric neurostimulation and probiotics, could reduce body weight and cardiovascular (CV) risk factors by attenuation of microbiota alterations. However, potential mechanisms of action have not been unveiled, and the prod...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/15/5/1067 |
| _version_ | 1797614684105342976 |
|---|---|
| author | Octavian Parascinet Sebastián Mas Tianyu Hang Carolina Llavero Óscar Lorenzo Jaime Ruiz-Tovar |
| author_facet | Octavian Parascinet Sebastián Mas Tianyu Hang Carolina Llavero Óscar Lorenzo Jaime Ruiz-Tovar |
| author_sort | Octavian Parascinet |
| collection | DOAJ |
| description | Previous data suggested that anti-obesity interventions, such as percutaneous electric neurostimulation and probiotics, could reduce body weight and cardiovascular (CV) risk factors by attenuation of microbiota alterations. However, potential mechanisms of action have not been unveiled, and the production of short-chain fatty acids (SCFAs) might be involved in these responses. This pilot study included two groups of class-I obese patients (N = 10, each) who underwent anti-obesity therapy by percutaneous electric neurostimulations (PENS) and a hypocaloric diet (Diet), with/without the administration of the multi-strain probiotic (<i>Lactobacillus plantarum</i> LP115, <i>Lactobacillus acidophilus</i> LA14, and <i>Bifidobacterium breve</i> B3), for ten weeks. Fecal samples were used for SCFA quantification (by HPLC-MS) in relation to microbiota and anthropometric and clinical variables. In these patients, we previously described a further reduction in obesity and CV risk factors (hyperglycemia, dyslipemia) after PENS-Diet+Prob compared to PENS-Diet alone. Herein, we observed that the administration of probiotics decreased fecal acetate concentrations, and this effect may be linked to the enrichment of <i>Prevotella</i>, <i>Bifidobacterium</i> spp., and <i>Akkermansia muciniphila</i>. Additionally, fecal acetate, propionate, and butyrate are associated with each other, suggesting an additional benefit in colonic absorption. In conclusion, probiotics could help anti-obesity interventions by promoting weight loss and reducing CV risk factors. Likely, modification of microbiota and related SCFA, such as acetate, could improve environmental conditions and permeability in the gut. |
| first_indexed | 2024-03-11T07:15:48Z |
| format | Article |
| id | doaj.art-b60ec3c77fbf431497ef22690d16dad4 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T07:15:48Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-b60ec3c77fbf431497ef22690d16dad42023-11-17T08:19:08ZengMDPI AGNutrients2072-66432023-02-01155106710.3390/nu15051067A Pilot Study: The Reduction in Fecal Acetate in Obese Patients after Probiotic Administration and Percutaneous Electrical NeurostimulationOctavian Parascinet0Sebastián Mas1Tianyu Hang2Carolina Llavero3Óscar Lorenzo4Jaime Ruiz-Tovar5Laboratory of Diabetes and Vascular pathology, IIS-Fundación Jiménez Díaz, Medicine Department, Universidad Autónoma, 28040 Madrid, SpainLaboratory of Diabetes and Vascular pathology, IIS-Fundación Jiménez Díaz, Medicine Department, Universidad Autónoma, 28040 Madrid, SpainLaboratory of Diabetes and Vascular pathology, IIS-Fundación Jiménez Díaz, Medicine Department, Universidad Autónoma, 28040 Madrid, SpainObesity Unit, Clinica Garcilaso, 28010 Madrid, SpainLaboratory of Diabetes and Vascular pathology, IIS-Fundación Jiménez Díaz, Medicine Department, Universidad Autónoma, 28040 Madrid, SpainObesity Unit, Clinica Garcilaso, 28010 Madrid, SpainPrevious data suggested that anti-obesity interventions, such as percutaneous electric neurostimulation and probiotics, could reduce body weight and cardiovascular (CV) risk factors by attenuation of microbiota alterations. However, potential mechanisms of action have not been unveiled, and the production of short-chain fatty acids (SCFAs) might be involved in these responses. This pilot study included two groups of class-I obese patients (N = 10, each) who underwent anti-obesity therapy by percutaneous electric neurostimulations (PENS) and a hypocaloric diet (Diet), with/without the administration of the multi-strain probiotic (<i>Lactobacillus plantarum</i> LP115, <i>Lactobacillus acidophilus</i> LA14, and <i>Bifidobacterium breve</i> B3), for ten weeks. Fecal samples were used for SCFA quantification (by HPLC-MS) in relation to microbiota and anthropometric and clinical variables. In these patients, we previously described a further reduction in obesity and CV risk factors (hyperglycemia, dyslipemia) after PENS-Diet+Prob compared to PENS-Diet alone. Herein, we observed that the administration of probiotics decreased fecal acetate concentrations, and this effect may be linked to the enrichment of <i>Prevotella</i>, <i>Bifidobacterium</i> spp., and <i>Akkermansia muciniphila</i>. Additionally, fecal acetate, propionate, and butyrate are associated with each other, suggesting an additional benefit in colonic absorption. In conclusion, probiotics could help anti-obesity interventions by promoting weight loss and reducing CV risk factors. Likely, modification of microbiota and related SCFA, such as acetate, could improve environmental conditions and permeability in the gut.https://www.mdpi.com/2072-6643/15/5/1067probioticsacetatepercutaneous electrical neurostimulation |
| spellingShingle | Octavian Parascinet Sebastián Mas Tianyu Hang Carolina Llavero Óscar Lorenzo Jaime Ruiz-Tovar A Pilot Study: The Reduction in Fecal Acetate in Obese Patients after Probiotic Administration and Percutaneous Electrical Neurostimulation Nutrients probiotics acetate percutaneous electrical neurostimulation |
| title | A Pilot Study: The Reduction in Fecal Acetate in Obese Patients after Probiotic Administration and Percutaneous Electrical Neurostimulation |
| title_full | A Pilot Study: The Reduction in Fecal Acetate in Obese Patients after Probiotic Administration and Percutaneous Electrical Neurostimulation |
| title_fullStr | A Pilot Study: The Reduction in Fecal Acetate in Obese Patients after Probiotic Administration and Percutaneous Electrical Neurostimulation |
| title_full_unstemmed | A Pilot Study: The Reduction in Fecal Acetate in Obese Patients after Probiotic Administration and Percutaneous Electrical Neurostimulation |
| title_short | A Pilot Study: The Reduction in Fecal Acetate in Obese Patients after Probiotic Administration and Percutaneous Electrical Neurostimulation |
| title_sort | pilot study the reduction in fecal acetate in obese patients after probiotic administration and percutaneous electrical neurostimulation |
| topic | probiotics acetate percutaneous electrical neurostimulation |
| url | https://www.mdpi.com/2072-6643/15/5/1067 |
| work_keys_str_mv | AT octavianparascinet apilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT sebastianmas apilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT tianyuhang apilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT carolinallavero apilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT oscarlorenzo apilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT jaimeruiztovar apilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT octavianparascinet pilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT sebastianmas pilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT tianyuhang pilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT carolinallavero pilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT oscarlorenzo pilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation AT jaimeruiztovar pilotstudythereductioninfecalacetateinobesepatientsafterprobioticadministrationandpercutaneouselectricalneurostimulation |