Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania
Abstract Background Current risk factors for lymph node metastasis in early gastric cancer have been primarily determined in Asian countries; however their applicability to Western nations is under discussion. The aim of our study was to identify risk factors associated with lymph node metastasis in...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | BMC Surgery |
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| Online Access: | http://link.springer.com/article/10.1186/s12893-017-0304-0 |
| _version_ | 1819208065503723520 |
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| author | Rimantas Bausys Augustinas Bausys Indre Vysniauskaite Kazimieras Maneikis Dalius Klimas Martynas Luksta Kestutis Strupas Eugenijus Stratilatovas |
| author_facet | Rimantas Bausys Augustinas Bausys Indre Vysniauskaite Kazimieras Maneikis Dalius Klimas Martynas Luksta Kestutis Strupas Eugenijus Stratilatovas |
| author_sort | Rimantas Bausys |
| collection | DOAJ |
| description | Abstract Background Current risk factors for lymph node metastasis in early gastric cancer have been primarily determined in Asian countries; however their applicability to Western nations is under discussion. The aim of our study was to identify risk factors associated with lymph node metastasis in Western cohort patients from the Eastern European country - Lithuania. Methods A total of 218 patients who underwent open gastrectomy for early gastric cancer were included in this retrospective study. After histolopathological examination, risk factors for lymph node metastasis were evaluated. Overall survival was evaluated and factors associated with long-term outcomes were analyzed. Results Lymph node metastases were present in 19.7% of early gastric cancer cases. The rates were 5/99 (4.95%) for pT1a tumors and 38/119 (31.9%) for pT1b tumors. Submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation were identified as independent risk factors for lymph node metastasis. Submucosal tumor invasion and lymphovascular invasion were also associated with worse 5-year survival results. Conclusion Our study established submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation as risk factors for lymph node metastasis. |
| first_indexed | 2024-12-23T05:33:28Z |
| format | Article |
| id | doaj.art-b6106feaa9954d3f9d9fc0c572087d3d |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-12-23T05:33:28Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-b6106feaa9954d3f9d9fc0c572087d3d2022-12-21T17:58:25ZengBMCBMC Surgery1471-24822017-11-011711810.1186/s12893-017-0304-0Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– LithuaniaRimantas Bausys0Augustinas Bausys1Indre Vysniauskaite2Kazimieras Maneikis3Dalius Klimas4Martynas Luksta5Kestutis Strupas6Eugenijus Stratilatovas7Department of Abdominal Surgery and Oncology, National Cancer InstituteDepartment of Abdominal Surgery and Oncology, National Cancer InstituteSchool of Medicine, Georgetown UniversityFaculty of Medicine, Vilnius UniversityFaculty of Medicine, Vilnius UniversityCenter of Abdominal surgery, Vilnius University Hospital Santaros KlinikosFaculty of Medicine, Vilnius UniversityDepartment of Abdominal Surgery and Oncology, National Cancer InstituteAbstract Background Current risk factors for lymph node metastasis in early gastric cancer have been primarily determined in Asian countries; however their applicability to Western nations is under discussion. The aim of our study was to identify risk factors associated with lymph node metastasis in Western cohort patients from the Eastern European country - Lithuania. Methods A total of 218 patients who underwent open gastrectomy for early gastric cancer were included in this retrospective study. After histolopathological examination, risk factors for lymph node metastasis were evaluated. Overall survival was evaluated and factors associated with long-term outcomes were analyzed. Results Lymph node metastases were present in 19.7% of early gastric cancer cases. The rates were 5/99 (4.95%) for pT1a tumors and 38/119 (31.9%) for pT1b tumors. Submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation were identified as independent risk factors for lymph node metastasis. Submucosal tumor invasion and lymphovascular invasion were also associated with worse 5-year survival results. Conclusion Our study established submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation as risk factors for lymph node metastasis.http://link.springer.com/article/10.1186/s12893-017-0304-0Early gastric cancerLymph node metastasisRisk factorsMucosal tumorT1a |
| spellingShingle | Rimantas Bausys Augustinas Bausys Indre Vysniauskaite Kazimieras Maneikis Dalius Klimas Martynas Luksta Kestutis Strupas Eugenijus Stratilatovas Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania BMC Surgery Early gastric cancer Lymph node metastasis Risk factors Mucosal tumor T1a |
| title | Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania |
| title_full | Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania |
| title_fullStr | Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania |
| title_full_unstemmed | Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania |
| title_short | Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania |
| title_sort | risk factors for lymph node metastasis in early gastric cancer patients report from eastern europe country lithuania |
| topic | Early gastric cancer Lymph node metastasis Risk factors Mucosal tumor T1a |
| url | http://link.springer.com/article/10.1186/s12893-017-0304-0 |
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