Fluorescence-guided minimally-invasive resection of abdominal paragangliomas using indocyanine green
Abstract This retrospective study explores the utility of near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) in enhancing the intraoperative identification and guidance for the resection of abdominal paragangliomas. They can be challenging to detect during minimally invasive surge...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-54718-1 |
| _version_ | 1797274743110369280 |
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| author | M. A. van Dam A. S. L. P. Crobach B. Boekestijn E. P. M. Corssmit B. A. Bonsing A. L. Vahrmeijer J. S. D. Mieog |
| author_facet | M. A. van Dam A. S. L. P. Crobach B. Boekestijn E. P. M. Corssmit B. A. Bonsing A. L. Vahrmeijer J. S. D. Mieog |
| author_sort | M. A. van Dam |
| collection | DOAJ |
| description | Abstract This retrospective study explores the utility of near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) in enhancing the intraoperative identification and guidance for the resection of abdominal paragangliomas. They can be challenging to detect during minimally invasive surgery, due to their anatomical location, varying size and similar appearance in regard to their surrounding tissue. Patients with suspected abdominal paragangliomas planned for a minimally-invasive resection were included. As part of standard of care they received single intravenous dose of 5 mg ICG after abdominal exploration. NIR fluorescence imaging of the anatomical region of the suspected lesion was performed immediately following intravenous administration, to assess fluorescence signals, intraoperative identification, and histopathological correlation. Out of five resected suspicious lesions, four were imaged with NIR fluorescence, pathology confirming four as paragangliomas, the latter turned out to be an adrenal adenoma. NIR fluorescence identified all four lesions, surpassing the limitations of white-light visualization. Homogeneous fluorescence signals appeared 30–60 s post-ICG administration, which lasted up to 30 min. The study demonstrates the feasibility and potential clinical value of fluorescence-guided minimally-invasive resections of abdominal paragangliomas using a single intravenous ICG dose. These findings support the scientific basis for routine use of ICG-fluorescence-guided surgery in challenging anatomical cases, providing valuable assistance in lesion detection and resection. |
| first_indexed | 2024-03-07T15:02:38Z |
| format | Article |
| id | doaj.art-b611bddd812346eebaa40374580136bb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:02:38Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b611bddd812346eebaa40374580136bb2024-03-05T19:04:39ZengNature PortfolioScientific Reports2045-23222024-02-011411810.1038/s41598-024-54718-1Fluorescence-guided minimally-invasive resection of abdominal paragangliomas using indocyanine greenM. A. van Dam0A. S. L. P. Crobach1B. Boekestijn2E. P. M. Corssmit3B. A. Bonsing4A. L. Vahrmeijer5J. S. D. Mieog6Department of Surgery, Leiden University Medical CenterDepartment of Pathology, Leiden University Medical CenterDepartment of Radiology, Leiden University Medical CenterDivision of Endocrinology, Department of Internal Medicine, Leiden University Medical CenterDepartment of Surgery, Leiden University Medical CenterDepartment of Surgery, Leiden University Medical CenterDepartment of Surgery, Leiden University Medical CenterAbstract This retrospective study explores the utility of near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) in enhancing the intraoperative identification and guidance for the resection of abdominal paragangliomas. They can be challenging to detect during minimally invasive surgery, due to their anatomical location, varying size and similar appearance in regard to their surrounding tissue. Patients with suspected abdominal paragangliomas planned for a minimally-invasive resection were included. As part of standard of care they received single intravenous dose of 5 mg ICG after abdominal exploration. NIR fluorescence imaging of the anatomical region of the suspected lesion was performed immediately following intravenous administration, to assess fluorescence signals, intraoperative identification, and histopathological correlation. Out of five resected suspicious lesions, four were imaged with NIR fluorescence, pathology confirming four as paragangliomas, the latter turned out to be an adrenal adenoma. NIR fluorescence identified all four lesions, surpassing the limitations of white-light visualization. Homogeneous fluorescence signals appeared 30–60 s post-ICG administration, which lasted up to 30 min. The study demonstrates the feasibility and potential clinical value of fluorescence-guided minimally-invasive resections of abdominal paragangliomas using a single intravenous ICG dose. These findings support the scientific basis for routine use of ICG-fluorescence-guided surgery in challenging anatomical cases, providing valuable assistance in lesion detection and resection.https://doi.org/10.1038/s41598-024-54718-1 |
| spellingShingle | M. A. van Dam A. S. L. P. Crobach B. Boekestijn E. P. M. Corssmit B. A. Bonsing A. L. Vahrmeijer J. S. D. Mieog Fluorescence-guided minimally-invasive resection of abdominal paragangliomas using indocyanine green Scientific Reports |
| title | Fluorescence-guided minimally-invasive resection of abdominal paragangliomas using indocyanine green |
| title_full | Fluorescence-guided minimally-invasive resection of abdominal paragangliomas using indocyanine green |
| title_fullStr | Fluorescence-guided minimally-invasive resection of abdominal paragangliomas using indocyanine green |
| title_full_unstemmed | Fluorescence-guided minimally-invasive resection of abdominal paragangliomas using indocyanine green |
| title_short | Fluorescence-guided minimally-invasive resection of abdominal paragangliomas using indocyanine green |
| title_sort | fluorescence guided minimally invasive resection of abdominal paragangliomas using indocyanine green |
| url | https://doi.org/10.1038/s41598-024-54718-1 |
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