Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese
Tetraspanin 2 (TSPAN2) belongs to the tetraspanin superfamily. Previous studies have identified significant associations of the TSPAN2 single nucleotide polymorphisms (SNPs) rs12134493 and rs2078371 with migraine in Western populations; however, these associations need to be confirmed in the Chinese...
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00714/full |
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| author | Jie Fang Xiaodong Yuan Xingkai An Hongli Qu Chen Wang Ganji Hong Liangcheng Zheng Kehui Yi Shuai Chen Xinrui Wang Qilin Ma Qilin Ma |
| author_facet | Jie Fang Xiaodong Yuan Xingkai An Hongli Qu Chen Wang Ganji Hong Liangcheng Zheng Kehui Yi Shuai Chen Xinrui Wang Qilin Ma Qilin Ma |
| author_sort | Jie Fang |
| collection | DOAJ |
| description | Tetraspanin 2 (TSPAN2) belongs to the tetraspanin superfamily. Previous studies have identified significant associations of the TSPAN2 single nucleotide polymorphisms (SNPs) rs12134493 and rs2078371 with migraine in Western populations; however, these associations need to be confirmed in the Chinese Han population. In addition, we carried out further studies to see whether TSPAN2 is associated with susceptibility to migraine to provide new clinical evidence. A case-control study (425 patients with migraine and 425 healthy controls) in a Chinese Han population was performed to evaluate the associations between migraine and TSPAN2 via a genotype-phenotype analysis between TSPAN2 and clinical symptoms. The SNP rs2078371 was found to be significantly associated with migraines especially in migraines without aura (MO) and in female patients. Meta-analysis revealed that the A allele of rs12134493 was significantly associated with migraines (OR = 1.14, P = 0.0001). Our findings suggested that TSPAN2 is a potential susceptibility factor for migraines. To confirm our results, a large-scale Chinese Han population study should be conducted. Considering that these two SNPs have not been definitively shown to affect TSPAN2 or to regulate nearby genes in this genomic region, the biological function and molecular mechanism of TSPAN2 in migraine should be further explored. |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T19:23:06Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-b611c329e54f4a62af2509761d9769482022-12-22T03:19:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-09-01910.3389/fneur.2018.00714400255Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han ChineseJie Fang0Xiaodong Yuan1Xingkai An2Hongli Qu3Chen Wang4Ganji Hong5Liangcheng Zheng6Kehui Yi7Shuai Chen8Xinrui Wang9Qilin Ma10Qilin Ma11Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Gynaecology and Obstetrics, Xiamen Maternal and Child Health Care Hospital, Xiamen, ChinaDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaGraduate School of Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, Zhongshan Xiamen Hospital, Fudan University, Xiamen, ChinaFujian Medical University, Fuzhou, ChinaState Key Laboratory for Medical Genomics, Shanghai Institute of Hematology, Rui-Jin Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaGraduate School of Fujian Medical University, Fuzhou, ChinaTetraspanin 2 (TSPAN2) belongs to the tetraspanin superfamily. Previous studies have identified significant associations of the TSPAN2 single nucleotide polymorphisms (SNPs) rs12134493 and rs2078371 with migraine in Western populations; however, these associations need to be confirmed in the Chinese Han population. In addition, we carried out further studies to see whether TSPAN2 is associated with susceptibility to migraine to provide new clinical evidence. A case-control study (425 patients with migraine and 425 healthy controls) in a Chinese Han population was performed to evaluate the associations between migraine and TSPAN2 via a genotype-phenotype analysis between TSPAN2 and clinical symptoms. The SNP rs2078371 was found to be significantly associated with migraines especially in migraines without aura (MO) and in female patients. Meta-analysis revealed that the A allele of rs12134493 was significantly associated with migraines (OR = 1.14, P = 0.0001). Our findings suggested that TSPAN2 is a potential susceptibility factor for migraines. To confirm our results, a large-scale Chinese Han population study should be conducted. Considering that these two SNPs have not been definitively shown to affect TSPAN2 or to regulate nearby genes in this genomic region, the biological function and molecular mechanism of TSPAN2 in migraine should be further explored.https://www.frontiersin.org/article/10.3389/fneur.2018.00714/fullmigraineTetraspanin 2TSPAN2SNPgenotype-phenotype analysis |
| spellingShingle | Jie Fang Xiaodong Yuan Xingkai An Hongli Qu Chen Wang Ganji Hong Liangcheng Zheng Kehui Yi Shuai Chen Xinrui Wang Qilin Ma Qilin Ma Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese Frontiers in Neurology migraine Tetraspanin 2 TSPAN2 SNP genotype-phenotype analysis |
| title | Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese |
| title_full | Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese |
| title_fullStr | Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese |
| title_full_unstemmed | Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese |
| title_short | Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese |
| title_sort | involvement of the tetraspanin 2 tspan2 gene in migraine a case control study in han chinese |
| topic | migraine Tetraspanin 2 TSPAN2 SNP genotype-phenotype analysis |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00714/full |
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