Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation
Platelet elevation is a rare manifestation in the peripheral blood of patients with chronic myeloid leukemia (CML). In this paper, we report for the first time a case of CML combined with cerebral hemorrhage manifested by abnormally elevated platelets. The patient had elevated platelets in the perip...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2024-01-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0377 |
| _version_ | 1797324496977264640 |
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| author | ZHANG Xin ZHANG Xiao GUO Yi FENG Jun XIAO Zhiyuan XIE Zhaoxiang WU Jing XU Dongrui WEI Junji WANG Yu |
| author_facet | ZHANG Xin ZHANG Xiao GUO Yi FENG Jun XIAO Zhiyuan XIE Zhaoxiang WU Jing XU Dongrui WEI Junji WANG Yu |
| author_sort | ZHANG Xin |
| collection | DOAJ |
| description | Platelet elevation is a rare manifestation in the peripheral blood of patients with chronic myeloid leukemia (CML). In this paper, we report for the first time a case of CML combined with cerebral hemorrhage manifested by abnormally elevated platelets. The patient had elevated platelets in the peripheral blood, showed normal coagulation function, and underwent intracranial hematoma removal due to cerebral hemorrhage. After the operation, bleeding from the operated area and other systems occurred, and the patient was diagnosed as having accelerated CML after combining bone marrow biopsy and genetic testing. His condition was controlled after administration of flumatinib through a jejunal tube. Based on this patient's experience, the feasibility ofadministering flumatinib via a jejunostomy tube was determined, which is the first report of its kind in China and abroad.This article summarizes the diagnosis and treatment process of this patient, with the aim of providing a warning and reference for clinicians. |
| first_indexed | 2024-03-08T05:56:57Z |
| format | Article |
| id | doaj.art-b612094cd979418288dd86780dbf36dc |
| institution | Directory Open Access Journal |
| issn | 1674-9081 |
| language | zho |
| last_indexed | 2024-03-08T05:56:57Z |
| publishDate | 2024-01-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj.art-b612094cd979418288dd86780dbf36dc2024-02-05T01:42:39ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812024-01-0115121722210.12290/xhyxzz.2023-0377Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal ElevationZHANG Xin0ZHANG Xiao1GUO Yi2FENG Jun3XIAO Zhiyuan4XIE Zhaoxiang5WU Jing6XU Dongrui7WEI Junji8WANG Yu9Department of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaPlatelet elevation is a rare manifestation in the peripheral blood of patients with chronic myeloid leukemia (CML). In this paper, we report for the first time a case of CML combined with cerebral hemorrhage manifested by abnormally elevated platelets. The patient had elevated platelets in the peripheral blood, showed normal coagulation function, and underwent intracranial hematoma removal due to cerebral hemorrhage. After the operation, bleeding from the operated area and other systems occurred, and the patient was diagnosed as having accelerated CML after combining bone marrow biopsy and genetic testing. His condition was controlled after administration of flumatinib through a jejunal tube. Based on this patient's experience, the feasibility ofadministering flumatinib via a jejunostomy tube was determined, which is the first report of its kind in China and abroad.This article summarizes the diagnosis and treatment process of this patient, with the aim of providing a warning and reference for clinicians.https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0377cerebral hemorrhageplatelet elevationchronic myeloid leukemia |
| spellingShingle | ZHANG Xin ZHANG Xiao GUO Yi FENG Jun XIAO Zhiyuan XIE Zhaoxiang WU Jing XU Dongrui WEI Junji WANG Yu Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation Xiehe Yixue Zazhi cerebral hemorrhage platelet elevation chronic myeloid leukemia |
| title | Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation |
| title_full | Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation |
| title_fullStr | Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation |
| title_full_unstemmed | Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation |
| title_short | Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation |
| title_sort | successful treatment of a patient with chronic myeloid leukemia complicated by cerebral hemorrhage manifesting as platelet abnormal elevation |
| topic | cerebral hemorrhage platelet elevation chronic myeloid leukemia |
| url | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0377 |
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