Basic concepts for sample size calculation: Critical step for any clinical trials!
Quality of clinical trials has improved steadily over last two decades, but certain areas in trial methodology still require special attention like in sample size calculation. The sample size is one of the basic steps in planning any clinical trial and any negligence in its calculation may lead to r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Saudi Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.saudija.org/article.asp?issn=1658-354X;year=2016;volume=10;issue=3;spage=328;epage=331;aulast=Gupta |
| _version_ | 1818258430653104128 |
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| author | K K Gupta J P Attri A Singh H Kaur G Kaur |
| author_facet | K K Gupta J P Attri A Singh H Kaur G Kaur |
| author_sort | K K Gupta |
| collection | DOAJ |
| description | Quality of clinical trials has improved steadily over last two decades, but certain areas in trial methodology still require special attention like in sample size calculation. The sample size is one of the basic steps in planning any clinical trial and any negligence in its calculation may lead to rejection of true findings and false results may get approval. Although statisticians play a major role in sample size estimation basic knowledge regarding sample size calculation is very sparse among most of the anesthesiologists related to research including under trainee doctors. In this review, we will discuss how important sample size calculation is for research studies and the effects of underestimation or overestimation of sample size on project′s results. We have highlighted the basic concepts regarding various parameters needed to calculate the sample size along with examples. |
| first_indexed | 2024-12-12T17:59:25Z |
| format | Article |
| id | doaj.art-b6132687853b4bc18227246ea4c4fac8 |
| institution | Directory Open Access Journal |
| issn | 1658-354X |
| language | English |
| last_indexed | 2024-12-12T17:59:25Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Anaesthesia |
| spelling | doaj.art-b6132687853b4bc18227246ea4c4fac82022-12-22T00:16:38ZengWolters Kluwer Medknow PublicationsSaudi Journal of Anaesthesia1658-354X2016-01-0110332833110.4103/1658-354X.174918Basic concepts for sample size calculation: Critical step for any clinical trials!K K GuptaJ P AttriA SinghH KaurG KaurQuality of clinical trials has improved steadily over last two decades, but certain areas in trial methodology still require special attention like in sample size calculation. The sample size is one of the basic steps in planning any clinical trial and any negligence in its calculation may lead to rejection of true findings and false results may get approval. Although statisticians play a major role in sample size estimation basic knowledge regarding sample size calculation is very sparse among most of the anesthesiologists related to research including under trainee doctors. In this review, we will discuss how important sample size calculation is for research studies and the effects of underestimation or overestimation of sample size on project′s results. We have highlighted the basic concepts regarding various parameters needed to calculate the sample size along with examples.http://www.saudija.org/article.asp?issn=1658-354X;year=2016;volume=10;issue=3;spage=328;epage=331;aulast=GuptaClinical trial; power of study; sample size |
| spellingShingle | K K Gupta J P Attri A Singh H Kaur G Kaur Basic concepts for sample size calculation: Critical step for any clinical trials! Saudi Journal of Anaesthesia Clinical trial; power of study; sample size |
| title | Basic concepts for sample size calculation: Critical step for any clinical trials! |
| title_full | Basic concepts for sample size calculation: Critical step for any clinical trials! |
| title_fullStr | Basic concepts for sample size calculation: Critical step for any clinical trials! |
| title_full_unstemmed | Basic concepts for sample size calculation: Critical step for any clinical trials! |
| title_short | Basic concepts for sample size calculation: Critical step for any clinical trials! |
| title_sort | basic concepts for sample size calculation critical step for any clinical trials |
| topic | Clinical trial; power of study; sample size |
| url | http://www.saudija.org/article.asp?issn=1658-354X;year=2016;volume=10;issue=3;spage=328;epage=331;aulast=Gupta |
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